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10.1242/dmm.049572 http://scihub22266oqcxt.onion/10.1242/dmm.049572 35438176!9194484!35438176     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Dis+Model+Mech 2022 ; 15 (5): ä Nephropedia Template TP {{tp|p=35438176|t=2022. Molecular signature of postmortem lung tissue from COVID-19 patients suggests distinct trajectories driving mortality |pdf=|usr=}}{{35438176}} gab.com Text Molecular signature of postmortem lung tissue from COVID-19 patients suggests distinct trajectories driving mortality JO: Dis Model Mech http://www.kidney.de/pget.php?&tw=1&pmid=35438176 #FOAvip To elucidate the molecular mechanisms that manifest lung abnormalities during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, we performed whole-transcriptome sequencing of lung autopsies from 31 patients with severe COVID-19 and ten uninfected controls. Using metatranscriptomics, we identified the existence of two distinct molecular signatures of lethal COVID-19. The dominant 'classical' signature (n=23) showed upregulation of the unfolded protein response, steroid biosynthesis and complement activation, supported by massive metabolic reprogramming leading to characteristic lung damage. The rarer signature (n=8) that potentially represents 'cytokine release syndrome' (CRS) showed upregulation of cytokines such as IL1 and CCL19, but absence of complement activation. We found that a majority of patients cleared SARS-CoV-2 infection, but they suffered from acute dysbiosis with characteristic enrichment of opportunistic pathogens such as Staphylococcus cohnii in 'classical' patients and Pasteurella multocida in CRS patients. Our results suggest two distinct models of lung pathology in severe COVID-19 patients, which can be identified through complement activation, presence of specific cytokines and characteristic microbiome. These findings can be used to design personalized therapy using in silico identified drug molecules or in mitigating specific secondary infections. Twit Text FOAVip Molecular signature of postmortem lung tissue from COVID-19 patients suggests distinct trajectories driving mortality ????Dis Model Mech http://www.kidney.de/pget.php?&tw=1&pmid=35438176 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35438176 #FOAvip English Wikipedia <ref>{{Cite pmid|35438176}}</ref> Molecular signature of postmortem lung tissue from COVID-19 patients suggests distinct trajectories driving mortality #MMPMID35438176 Budhraja A; Basu A; Gheware A; Abhilash D; Rajagopala S; Pakala S; Sumit M; Ray A; Subramaniam A; Mathur P; Nambirajan A; Kumar S; Gupta R; Wig N; Trikha A; Guleria R; Sarkar C; Gupta I; Jain D Dis Model Mech 2022[May]; 15 (5): ä PMID35438176show ga To elucidate the molecular mechanisms that manifest lung abnormalities during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, we performed whole-transcriptome sequencing of lung autopsies from 31 patients with severe COVID-19 and ten uninfected controls. Using metatranscriptomics, we identified the existence of two distinct molecular signatures of lethal COVID-19. The dominant 'classical' signature (n=23) showed upregulation of the unfolded protein response, steroid biosynthesis and complement activation, supported by massive metabolic reprogramming leading to characteristic lung damage. The rarer signature (n=8) that potentially represents 'cytokine release syndrome' (CRS) showed upregulation of cytokines such as IL1 and CCL19, but absence of complement activation. We found that a majority of patients cleared SARS-CoV-2 infection, but they suffered from acute dysbiosis with characteristic enrichment of opportunistic pathogens such as Staphylococcus cohnii in 'classical' patients and Pasteurella multocida in CRS patients. Our results suggest two distinct models of lung pathology in severe COVID-19 patients, which can be identified through complement activation, presence of specific cytokines and characteristic microbiome. These findings can be used to design personalized therapy using in silico identified drug molecules or in mitigating specific secondary infections. |*COVID-19[MESH] |Autopsy[MESH] |Cytokines[MESH] |Humans[MESH] |Lung/pathology[MESH]Molecular signature of postmortem lung tissue from COVID-19 patients s(epmc).pdf DeepDyve Pubget Overpricing