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10.3389/fphys.2022.828093 http://scihub22266oqcxt.onion/10.3389/fphys.2022.828093 35431977!9008570!35431977     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Physiol 2022 ; 13 (ä): 828093 Nephropedia Template TP {{tp|p=35431977|t=2022. Endothelial Transcytosis in Acute Lung Injury: Emerging Mechanisms and Therapeutic Approaches |pdf=|usr=}}{{35431977}} gab.com Text Endothelial Transcytosis in Acute Lung Injury: Emerging Mechanisms and Therapeutic Approaches JO: Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=35431977 #FOAvip Acute Lung Injury (ALI) is characterized by widespread inflammation which in its severe form, Acute Respiratory Distress Syndrome (ARDS), leads to compromise in respiration causing hypoxemia and death in a substantial number of affected individuals. Loss of endothelial barrier integrity, pneumocyte necrosis, and circulating leukocyte recruitment into the injured lung are recognized mechanisms that contribute to the progression of ALI/ARDS. Additionally, damage to the pulmonary microvasculature by Gram-negative and positive bacteria or viruses (e.g., Escherichia coli, SARS-Cov-2) leads to increased protein and fluid permeability and interstitial edema, further impairing lung function. While most of the vascular leakage is attributed to loss of inter-endothelial junctional integrity, studies in animal models suggest that transendothelial transport of protein through caveolar vesicles, known as transcytosis, occurs in the early phase of ALI/ARDS. Here, we discuss the role of transcytosis in healthy and injured endothelium and highlight recent studies that have contributed to our understanding of the process during ALI/ARDS. We also cover potential approaches that utilize caveolar transport to deliver therapeutics to the lungs which may prevent further injury or improve recovery. Twit Text FOAVip Endothelial Transcytosis in Acute Lung Injury: Emerging Mechanisms and Therapeutic Approaches ????Front Physiol http://www.kidney.de/pget.php?&tw=1&pmid=35431977 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35431977 #FOAvip English Wikipedia <ref>{{Cite pmid|35431977}}</ref> Endothelial Transcytosis in Acute Lung Injury: Emerging Mechanisms and Therapeutic Approaches #MMPMID35431977 Jones JH; Minshall RD Front Physiol 2022[]; 13 (ä): 828093 PMID35431977show ga Acute Lung Injury (ALI) is characterized by widespread inflammation which in its severe form, Acute Respiratory Distress Syndrome (ARDS), leads to compromise in respiration causing hypoxemia and death in a substantial number of affected individuals. Loss of endothelial barrier integrity, pneumocyte necrosis, and circulating leukocyte recruitment into the injured lung are recognized mechanisms that contribute to the progression of ALI/ARDS. Additionally, damage to the pulmonary microvasculature by Gram-negative and positive bacteria or viruses (e.g., Escherichia coli, SARS-Cov-2) leads to increased protein and fluid permeability and interstitial edema, further impairing lung function. While most of the vascular leakage is attributed to loss of inter-endothelial junctional integrity, studies in animal models suggest that transendothelial transport of protein through caveolar vesicles, known as transcytosis, occurs in the early phase of ALI/ARDS. Here, we discuss the role of transcytosis in healthy and injured endothelium and highlight recent studies that have contributed to our understanding of the process during ALI/ARDS. We also cover potential approaches that utilize caveolar transport to deliver therapeutics to the lungs which may prevent further injury or improve recovery. äEndothelial Transcytosis in Acute Lung Injury: Emerging Mechanisms and(epmc).pdf DeepDyve Pubget Overpricing