| 10.1161/CIRCRESAHA.121.320090
http://scihub22266oqcxt.onion/10.1161/CIRCRESAHA.121.320090
35430876!9286288!35430876 free free free
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Circ+Res 2022 ; 130 (10): 1510-1530 Nephropedia Template TP
gab.com Text
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Human Coronary Plaque T Cells Are Clonal and Cross-React to Virus and Self #MMPMID35430876Chowdhury RR; D'Addabbo J; Huang X; Veizades S; Sasagawa K; Louis DM; Cheng P; Sokol J; Jensen A; Tso A; Shankar V; Wendel BS; Bakerman I; Liang G; Koyano T; Fong R; Nau AN; Ahmad H; Gopakumar J; Wirka R; Lee AS; Boyd J; Woo YJ; Quertermous T; Gulati GS; Jaiswal S; Chien YH; Chan CKF; Davis MM; Nguyen PKCirc Res 2022[May]; 130 (10): 1510-1530 PMID35430876show ga
BACKGROUND: Coronary artery disease is an incurable, life-threatening disease that was once considered primarily a disorder of lipid deposition. Coronary artery disease is now also characterized by chronic inflammation' notable for the buildup of atherosclerotic plaques containing immune cells in various states of activation and differentiation. Understanding how these immune cells contribute to disease progression may lead to the development of novel therapeutic strategies. METHODS: We used single-cell technology and in vitro assays to interrogate the immune microenvironment of human coronary atherosclerotic plaque at different stages of maturity. RESULTS: In addition to macrophages, we found a high proportion of alphabeta T cells in the coronary plaques. Most of these T cells lack high expression of CCR7 and L-selectin, indicating that they are primarily antigen-experienced memory cells. Notably, nearly one-third of these cells express the HLA-DRA surface marker, signifying activation through their TCRs (T-cell receptors). Consistent with this, TCR repertoire analysis confirmed the presence of activated alphabeta T cells (CD4 |
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