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10.1016/j.celrep.2022.110714 http://scihub22266oqcxt.onion/10.1016/j.celrep.2022.110714 35421379!8977517!35421379     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Rep 2022 ; 39 (3): 110714 Nephropedia Template TP {{tp|p=35421379|t=2022. Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection |pdf=|usr=}}{{35421379}} gab.com Text Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=35421379 #FOAvip The human immunological mechanisms defining the clinical outcome of SARS-CoV-2 infection remain elusive. This knowledge gap is mostly driven by the lack of appropriate experimental platforms recapitulating human immune responses in a controlled human lung environment. Here, we report a mouse model (i.e., HNFL mice) co-engrafted with human fetal lung xenografts (fLX) and a myeloid-enhanced human immune system to identify cellular and molecular correlates of lung protection during SARS-CoV-2 infection. Unlike mice solely engrafted with human fLX, HNFL mice are protected against infection, severe inflammation, and histopathological phenotypes. Lung tissue protection from infection and severe histopathology associates with macrophage infiltration and differentiation and the upregulation of a macrophage-enriched signature composed of 11 specific genes mainly associated with the type I interferon signaling pathway. Our work highlights the HNFL model as a transformative platform to investigate, in controlled experimental settings, human myeloid immune mechanisms governing lung tissue protection during SARS-CoV-2 infection. Twit Text FOAVip Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=35421379 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35421379 #FOAvip English Wikipedia <ref>{{Cite pmid|35421379}}</ref> Humanized mice reveal a macrophage-enriched gene signature defining human lung tissue protection during SARS-CoV-2 infection #MMPMID35421379 Kenney DJ; O'Connell AK; Turcinovic J; Montanaro P; Hekman RM; Tamura T; Berneshawi AR; Cafiero TR; Al Abdullatif S; Blum B; Goldstein SI; Heller BL; Gertje HP; Bullitt E; Trachtenberg AJ; Chavez E; Nono ET; Morrison C; Tseng AE; Sheikh A; Kurnick S; Grosz K; Bosmann M; Ericsson M; Huber BR; Saeed M; Balazs AB; Francis KP; Klose A; Paragas N; Campbell JD; Connor JH; Emili A; Crossland NA; Ploss A; Douam F Cell Rep 2022[Apr]; 39 (3): 110714 PMID35421379show ga The human immunological mechanisms defining the clinical outcome of SARS-CoV-2 infection remain elusive. This knowledge gap is mostly driven by the lack of appropriate experimental platforms recapitulating human immune responses in a controlled human lung environment. Here, we report a mouse model (i.e., HNFL mice) co-engrafted with human fetal lung xenografts (fLX) and a myeloid-enhanced human immune system to identify cellular and molecular correlates of lung protection during SARS-CoV-2 infection. Unlike mice solely engrafted with human fLX, HNFL mice are protected against infection, severe inflammation, and histopathological phenotypes. Lung tissue protection from infection and severe histopathology associates with macrophage infiltration and differentiation and the upregulation of a macrophage-enriched signature composed of 11 specific genes mainly associated with the type I interferon signaling pathway. Our work highlights the HNFL model as a transformative platform to investigate, in controlled experimental settings, human myeloid immune mechanisms governing lung tissue protection during SARS-CoV-2 infection. |*COVID-19/genetics[MESH] |Animals[MESH] |Disease Models, Animal[MESH] |Humans[MESH] |Immunity, Innate[MESH] |Lung/pathology[MESH] |Macrophages[MESH] |Mice[MESH]Humanized mice reveal a macrophage-enriched gene signature defining hu(epmc).pdf DeepDyve Pubget Overpricing