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10.1371/journal.pone.0264979 http://scihub22266oqcxt.onion/10.1371/journal.pone.0264979 35421120!9009616!35421120     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2022 ; 17 (4): e0264979 Nephropedia Template TP {{tp|p=35421120|t=2022. Dysregulation of the leukocyte signaling landscape during acute COVID-19 |pdf=|usr=}}{{35421120}} gab.com Text Dysregulation of the leukocyte signaling landscape during acute COVID-19 JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=35421120 #FOAvip The global COVID-19 pandemic has claimed the lives of more than 750,000 US citizens. Dysregulation of the immune system underlies the pathogenesis of COVID-19, with inflammation mediated tissue injury to the lung in the setting of suppressed systemic immune function. To define the molecular mechanisms of immune dysfunction in COVID-19 we utilized a systems immunology approach centered on the circulating leukocyte phosphoproteome measured by mass cytometry. We find that although COVID-19 is associated with wholesale activation of a broad set of signaling pathways across myeloid and lymphoid cell populations, STAT3 phosphorylation predominated in both monocytes and T cells. STAT3 phosphorylation was tightly correlated with circulating IL-6 levels and high levels of phospho-STAT3 was associated with decreased markers of myeloid cell maturation/activation and decreased ex-vivo T cell IFN-gamma production, demonstrating that during COVID-19 dysregulated cellular activation is associated with suppression of immune effector cell function. Collectively, these data reconcile the systemic inflammatory response and functional immunosuppression induced by COVID-19 and suggest STAT3 signaling may be the central pathophysiologic mechanism driving immune dysfunction in COVID-19. Twit Text FOAVip Dysregulation of the leukocyte signaling landscape during acute COVID-19 ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=35421120 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35421120 #FOAvip English Wikipedia <ref>{{Cite pmid|35421120}}</ref> Dysregulation of the leukocyte signaling landscape during acute COVID-19 #MMPMID35421120 Turnbull IR; Fuchs A; Remy KE; Kelly MP; Frazier EP; Ghosh S; Chang SW; Mazer MB; Hess A; Leonard JM; Hoofnagle MH; Colonna M; Hotchkiss RS PLoS One 2022[]; 17 (4): e0264979 PMID35421120show ga The global COVID-19 pandemic has claimed the lives of more than 750,000 US citizens. Dysregulation of the immune system underlies the pathogenesis of COVID-19, with inflammation mediated tissue injury to the lung in the setting of suppressed systemic immune function. To define the molecular mechanisms of immune dysfunction in COVID-19 we utilized a systems immunology approach centered on the circulating leukocyte phosphoproteome measured by mass cytometry. We find that although COVID-19 is associated with wholesale activation of a broad set of signaling pathways across myeloid and lymphoid cell populations, STAT3 phosphorylation predominated in both monocytes and T cells. STAT3 phosphorylation was tightly correlated with circulating IL-6 levels and high levels of phospho-STAT3 was associated with decreased markers of myeloid cell maturation/activation and decreased ex-vivo T cell IFN-gamma production, demonstrating that during COVID-19 dysregulated cellular activation is associated with suppression of immune effector cell function. Collectively, these data reconcile the systemic inflammatory response and functional immunosuppression induced by COVID-19 and suggest STAT3 signaling may be the central pathophysiologic mechanism driving immune dysfunction in COVID-19. |*COVID-19[MESH] |Humans[MESH] |Monocytes/metabolism[MESH] |Pandemics[MESH] |STAT3 Transcription Factor/metabolism[MESH] |Signal Transduction[MESH]Dysregulation of the leukocyte signaling landscape during acute COVID-(epmc).pdf DeepDyve Pubget Overpricing