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10.1371/journal.pgen.1010137 http://scihub22266oqcxt.onion/10.1371/journal.pgen.1010137 35421082!9089920!35421082     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Genet 2022 ; 18 (4): e1010137 Nephropedia Template TP {{tp|p=35421082|t=2022. Abnormal global alternative RNA splicing in COVID-19 patients |pdf=|usr=}}{{35421082}} gab.com Text Abnormal global alternative RNA splicing in COVID-19 patients JO: PLoS Genet http://www.kidney.de/pget.php?&tw=1&pmid=35421082 #FOAvip Viral infections can alter host transcriptomes by manipulating host splicing machinery. Despite intensive transcriptomic studies on SARS-CoV-2, a systematic analysis of alternative splicing (AS) in severe COVID-19 patients remains largely elusive. Here we integrated proteomic and transcriptomic sequencing data to study AS changes in COVID-19 patients. We discovered that RNA splicing is among the major down-regulated proteomic signatures in COVID-19 patients. The transcriptome analysis showed that SARS-CoV-2 infection induces widespread dysregulation of transcript usage and expression, affecting blood coagulation, neutrophil activation, and cytokine production. Notably, CD74 and LRRFIP1 had increased skipping of an exon in COVID-19 patients that disrupts a functional domain, which correlated with reduced antiviral immunity. Furthermore, the dysregulation of transcripts was strongly correlated with clinical severity of COVID-19, and splice-variants may contribute to unexpected therapeutic activity. In summary, our data highlight that a better understanding of the AS landscape may aid in COVID-19 diagnosis and therapy. Twit Text FOAVip Abnormal global alternative RNA splicing in COVID-19 patients ????PLoS Genet http://www.kidney.de/pget.php?&tw=1&pmid=35421082 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35421082 #FOAvip English Wikipedia <ref>{{Cite pmid|35421082}}</ref> Abnormal global alternative RNA splicing in COVID-19 patients #MMPMID35421082 Wang C; Chen L; Chen Y; Jia W; Cai X; Liu Y; Ji F; Xiong P; Liang A; Liu R; Guan Y; Cheng Z; Weng Y; Wang W; Duan Y; Kuang D; Xu S; Cai H; Xia Q; Yang D; Wang MW; Yang X; Zhang J; Cheng C; Liu L; Liu Z; Liang R; Wang G; Li Z; Xia H; Xia T PLoS Genet 2022[Apr]; 18 (4): e1010137 PMID35421082show ga Viral infections can alter host transcriptomes by manipulating host splicing machinery. Despite intensive transcriptomic studies on SARS-CoV-2, a systematic analysis of alternative splicing (AS) in severe COVID-19 patients remains largely elusive. Here we integrated proteomic and transcriptomic sequencing data to study AS changes in COVID-19 patients. We discovered that RNA splicing is among the major down-regulated proteomic signatures in COVID-19 patients. The transcriptome analysis showed that SARS-CoV-2 infection induces widespread dysregulation of transcript usage and expression, affecting blood coagulation, neutrophil activation, and cytokine production. Notably, CD74 and LRRFIP1 had increased skipping of an exon in COVID-19 patients that disrupts a functional domain, which correlated with reduced antiviral immunity. Furthermore, the dysregulation of transcripts was strongly correlated with clinical severity of COVID-19, and splice-variants may contribute to unexpected therapeutic activity. In summary, our data highlight that a better understanding of the AS landscape may aid in COVID-19 diagnosis and therapy. |*COVID-19/genetics[MESH] |Alternative Splicing/genetics[MESH] |COVID-19 Testing[MESH] |Humans[MESH] |Proteomics[MESH] |SARS-CoV-2/genetics[MESH]Abnormal global alternative RNA splicing in COVID-19 patients (epmc).pdf DeepDyve Pubget Overpricing