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10.1038/s41467-022-29659-w

http://scihub22266oqcxt.onion/10.1038/s41467-022-29659-w
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35418199!9007988!35418199
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suck abstract from ncbi


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pmid35418199      Nat+Commun 2022 ; 13 (1): 1985
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  • Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer #MMPMID35418199
  • Guillot J; Dominici C; Lucchesi A; Nguyen HTT; Puget A; Hocine M; Rangel-Sosa MM; Simic M; Nigri J; Guillaumond F; Bigonnet M; Dusetti N; Perrot J; Lopez J; Etzerodt A; Lawrence T; Pudlo P; Hubert F; Scoazec JY; van de Pavert SA; Tomasini R; Chauvet S; Mann F
  • Nat Commun 2022[Apr]; 13 (1): 1985 PMID35418199show ga
  • Neuronal nerve processes in the tumor microenvironment were highlighted recently. However, the origin of intra-tumoral nerves remains poorly known, in part because of technical difficulties in tracing nerve fibers via conventional histological preparations. Here, we employ three-dimensional (3D) imaging of cleared tissues for a comprehensive analysis of sympathetic innervation in a murine model of pancreatic ductal adenocarcinoma (PDAC). Our results support two independent, but coexisting, mechanisms: passive engulfment of pre-existing sympathetic nerves within tumors plus an active, localized sprouting of axon terminals into non-neoplastic lesions and tumor periphery. Ablation of the innervating sympathetic nerves increases tumor growth and spread. This effect is explained by the observation that sympathectomy increases intratumoral CD163(+) macrophage numbers, which contribute to the worse outcome. Altogether, our findings provide insights into the mechanisms by which the sympathetic nervous system exerts cancer-protective properties in a mouse model of PDAC.
  • |*Carcinoma, Pancreatic Ductal[MESH]
  • |*Pancreatic Neoplasms[MESH]
  • |Animals[MESH]
  • |Macrophages[MESH]
  • |Mice[MESH]
  • |Sympathetic Nervous System/physiology[MESH]


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