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10.1038/s41467-022-29659-w http://scihub22266oqcxt.onion/10.1038/s41467-022-29659-w 35418199!9007988!35418199     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35418199.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2022 ; 13 (1): 1985 Nephropedia Template TP {{tp|p=35418199|t=2022. Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer |pdf=|usr=}}{{35418199}} gab.com Text Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=35418199 #FOAvip Neuronal nerve processes in the tumor microenvironment were highlighted recently. However, the origin of intra-tumoral nerves remains poorly known, in part because of technical difficulties in tracing nerve fibers via conventional histological preparations. Here, we employ three-dimensional (3D) imaging of cleared tissues for a comprehensive analysis of sympathetic innervation in a murine model of pancreatic ductal adenocarcinoma (PDAC). Our results support two independent, but coexisting, mechanisms: passive engulfment of pre-existing sympathetic nerves within tumors plus an active, localized sprouting of axon terminals into non-neoplastic lesions and tumor periphery. Ablation of the innervating sympathetic nerves increases tumor growth and spread. This effect is explained by the observation that sympathectomy increases intratumoral CD163(+) macrophage numbers, which contribute to the worse outcome. Altogether, our findings provide insights into the mechanisms by which the sympathetic nervous system exerts cancer-protective properties in a mouse model of PDAC. Twit Text FOAVip Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=35418199 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35418199 #FOAvip English Wikipedia <ref>{{Cite pmid|35418199}}</ref> Sympathetic axonal sprouting induces changes in macrophage populations and protects against pancreatic cancer #MMPMID35418199 Guillot J; Dominici C; Lucchesi A; Nguyen HTT; Puget A; Hocine M; Rangel-Sosa MM; Simic M; Nigri J; Guillaumond F; Bigonnet M; Dusetti N; Perrot J; Lopez J; Etzerodt A; Lawrence T; Pudlo P; Hubert F; Scoazec JY; van de Pavert SA; Tomasini R; Chauvet S; Mann F Nat Commun 2022[Apr]; 13 (1): 1985 PMID35418199show ga Neuronal nerve processes in the tumor microenvironment were highlighted recently. However, the origin of intra-tumoral nerves remains poorly known, in part because of technical difficulties in tracing nerve fibers via conventional histological preparations. Here, we employ three-dimensional (3D) imaging of cleared tissues for a comprehensive analysis of sympathetic innervation in a murine model of pancreatic ductal adenocarcinoma (PDAC). Our results support two independent, but coexisting, mechanisms: passive engulfment of pre-existing sympathetic nerves within tumors plus an active, localized sprouting of axon terminals into non-neoplastic lesions and tumor periphery. Ablation of the innervating sympathetic nerves increases tumor growth and spread. This effect is explained by the observation that sympathectomy increases intratumoral CD163(+) macrophage numbers, which contribute to the worse outcome. Altogether, our findings provide insights into the mechanisms by which the sympathetic nervous system exerts cancer-protective properties in a mouse model of PDAC. |*Carcinoma, Pancreatic Ductal[MESH] |*Pancreatic Neoplasms[MESH] |Animals[MESH] |Macrophages[MESH] |Mice[MESH] |Sympathetic Nervous System/physiology[MESH]Sympathetic axonal sprouting induces changes in macrophage populations(epmc).pdf DeepDyve Pubget Overpricing