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10.1126/scisignal.abg8744 http://scihub22266oqcxt.onion/10.1126/scisignal.abg8744 35412852!ä!35412852 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Signal 2022 ; 15 (729): eabg8744 Nephropedia Template TP {{tp|p=35412852|t=2022. SARS-CoV-2 spike protein-induced cell fusion activates the cGAS-STING pathway and the interferon response |pdf=|usr=}}{{35412852}} gab.com Text SARS-CoV-2 spike protein-induced cell fusion activates the cGAS-STING pathway and the interferon response JO: Sci Signal http://www.kidney.de/pget.php?&tw=1&pmid=35412852 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the unprecedented coronavirus disease 2019 (COVID-19) pandemic. Critical cases of COVID-19 are characterized by the production of excessive amounts of cytokines and extensive lung damage, which is partially caused by the fusion of SARS-CoV-2-infected pneumocytes. Here, we found that cell fusion caused by the SARS-CoV-2 spike (S) protein induced a type I interferon (IFN) response. This function of the S protein required its cleavage by proteases at the S1/S2 and the S2' sites. We further showed that cell fusion damaged nuclei and resulted in the formation of micronuclei that were sensed by the cytosolic DNA sensor cGAS and led to the activation of its downstream effector STING. Phosphorylation of the transcriptional regulator IRF3 and the expression of IFNB, which encodes a type I IFN, were abrogated in cGAS-deficient fused cells. Moreover, infection with VSV-SARS-CoV-2 also induced cell fusion, DNA damage, and cGAS-STING-dependent expression of IFNB. Together, these results uncover a pathway underlying the IFN response to SARS-CoV-2 infection. Our data suggest a mechanism by which fused pneumocytes in the lungs of patients with COVID-19 may enhance the production of IFNs and other cytokines, thus exacerbating disease severity. Twit Text FOAVip SARS-CoV-2 spike protein-induced cell fusion activates the cGAS-STING pathway and the interferon response ????Sci Signal http://www.kidney.de/pget.php?&tw=1&pmid=35412852 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35412852 #FOAvip English Wikipedia <ref>{{Cite pmid|35412852}}</ref> SARS-CoV-2 spike protein-induced cell fusion activates the cGAS-STING pathway and the interferon response #MMPMID35412852 Liu X; Wei L; Xu F; Zhao F; Huang Y; Fan Z; Mei S; Hu Y; Zhai L; Guo J; Zheng A; Cen S; Liang C; Guo F Sci Signal 2022[Apr]; 15 (729): eabg8744 PMID35412852show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the unprecedented coronavirus disease 2019 (COVID-19) pandemic. Critical cases of COVID-19 are characterized by the production of excessive amounts of cytokines and extensive lung damage, which is partially caused by the fusion of SARS-CoV-2-infected pneumocytes. Here, we found that cell fusion caused by the SARS-CoV-2 spike (S) protein induced a type I interferon (IFN) response. This function of the S protein required its cleavage by proteases at the S1/S2 and the S2' sites. We further showed that cell fusion damaged nuclei and resulted in the formation of micronuclei that were sensed by the cytosolic DNA sensor cGAS and led to the activation of its downstream effector STING. Phosphorylation of the transcriptional regulator IRF3 and the expression of IFNB, which encodes a type I IFN, were abrogated in cGAS-deficient fused cells. Moreover, infection with VSV-SARS-CoV-2 also induced cell fusion, DNA damage, and cGAS-STING-dependent expression of IFNB. Together, these results uncover a pathway underlying the IFN response to SARS-CoV-2 infection. Our data suggest a mechanism by which fused pneumocytes in the lungs of patients with COVID-19 may enhance the production of IFNs and other cytokines, thus exacerbating disease severity. |*COVID-19/genetics[MESH] |*Interferon Type I/genetics[MESH] |Cell Fusion[MESH] |Cytokines[MESH] |Humans[MESH] |Membrane Proteins/metabolism[MESH] |Nucleotidyltransferases/genetics/metabolism[MESH] |SARS-CoV-2[MESH]SARS-CoV-2 spike protein-induced cell fusion activates the cGAS-STING (epmc).pdf DeepDyve Pubget Overpricing