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10.1038/s41588-022-01042-x http://scihub22266oqcxt.onion/10.1038/s41588-022-01042-x 35410379!ä!35410379 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Genet 2022 ; 54 (4): 374-381 Nephropedia Template TP {{tp|p=35410379|t=2022. Expanded COVID-19 phenotype definitions reveal distinct patterns of genetic association and protective effects |pdf=|usr=}}{{35410379}} gab.com Text Expanded COVID-19 phenotype definitions reveal distinct patterns of genetic association and protective effects JO: Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=35410379 #FOAvip Multiple COVID-19 genome-wide association studies (GWASs) have identified reproducible genetic associations indicating that there is a genetic component to susceptibility and severity risk. To complement these studies, we collected deep coronavirus disease 2019 (COVID-19) phenotype data from a survey of 736,723 AncestryDNA research participants. With these data, we defined eight phenotypes related to COVID-19 outcomes: four phenotypes that align with previously studied COVID-19 definitions and four 'expanded' phenotypes that focus on susceptibility given exposure, mild clinical manifestations and an aggregate score of symptom severity. We performed a replication analysis of 12 previously reported COVID-19 genetic associations with all eight phenotypes in a trans-ancestry meta-analysis of AncestryDNA research participants. In this analysis, we show distinct patterns of association at the 12 loci with the eight outcomes that we assessed. We also performed a genome-wide discovery analysis of all eight phenotypes, which did not yield new genome-wide significant loci but did suggest that three of the four '?expanded'? COVID-19 phenotypes have enhanced power to capture protective genetic associations relative to the previously studied phenotypes. Thus, we conclude that continued large-scale ascertainment of deep COVID-19 phenotype data would likely represent a boon for COVID-19 therapeutic target identification. Twit Text FOAVip Expanded COVID-19 phenotype definitions reveal distinct patterns of genetic association and protective effects ????Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=35410379 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35410379 #FOAvip English Wikipedia <ref>{{Cite pmid|35410379}}</ref> Expanded COVID-19 phenotype definitions reveal distinct patterns of genetic association and protective effects #MMPMID35410379 Roberts GHL; Partha R; Rhead B; Knight SC; Park DS; Coignet MV; Zhang M; Berkowitz N; Turrisini DA; Gaddis M; McCurdy SR; Pavlovic M; Ruiz L; Sass C; Haug Baltzell AK; Guturu H; Girshick AR; Ball CA; Hong EL; Rand KA Nat Genet 2022[Apr]; 54 (4): 374-381 PMID35410379show ga Multiple COVID-19 genome-wide association studies (GWASs) have identified reproducible genetic associations indicating that there is a genetic component to susceptibility and severity risk. To complement these studies, we collected deep coronavirus disease 2019 (COVID-19) phenotype data from a survey of 736,723 AncestryDNA research participants. With these data, we defined eight phenotypes related to COVID-19 outcomes: four phenotypes that align with previously studied COVID-19 definitions and four 'expanded' phenotypes that focus on susceptibility given exposure, mild clinical manifestations and an aggregate score of symptom severity. We performed a replication analysis of 12 previously reported COVID-19 genetic associations with all eight phenotypes in a trans-ancestry meta-analysis of AncestryDNA research participants. In this analysis, we show distinct patterns of association at the 12 loci with the eight outcomes that we assessed. We also performed a genome-wide discovery analysis of all eight phenotypes, which did not yield new genome-wide significant loci but did suggest that three of the four '?expanded'? COVID-19 phenotypes have enhanced power to capture protective genetic associations relative to the previously studied phenotypes. Thus, we conclude that continued large-scale ascertainment of deep COVID-19 phenotype data would likely represent a boon for COVID-19 therapeutic target identification. |*COVID-19/genetics[MESH] |*Genome-Wide Association Study[MESH] |Genetic Predisposition to Disease[MESH] |Humans[MESH] |Phenotype[MESH]Expanded COVID-19 phenotype definitions reveal distinct patterns of ge(epmc).pdf DeepDyve Pubget Overpricing