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10.3390/nu14071445

http://scihub22266oqcxt.onion/10.3390/nu14071445
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suck abstract from ncbi


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pmid35406057      Nutrients 2022 ; 14 (7): ä
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  • Calcium, Magnesium, and Zinc Supplementation during Pregnancy: The Additive Value of Micronutrients on Maternal Immune Response after SARS-CoV-2 Infection #MMPMID35406057
  • Citu IM; Citu C; Margan MM; Craina M; Neamtu R; Gorun OM; Burlea B; Bratosin F; Rosca O; Grigoras ML; Motoc A; Malita D; Neagoe O; Gorun F
  • Nutrients 2022[Mar]; 14 (7): ä PMID35406057show ga
  • Magnesium may contribute to the immune response during and after SARS-CoV-2 infection by acting as a cofactor for immunoglobulin production and other processes required for T and B cell activity. Considering magnesium as a recommended dietary supplement during pregnancy and the possible role of magnesium deficiency in COVID-19 and its complications, the current study sought to determine the effect of magnesium and magnesium-containing nutritional supplements on the immune response following SARS-CoV-2 infection in pregnant women, as well as to observe differences in pregnancy outcomes based on the supplements taken during pregnancy. The study followed a cross-sectional design, where patients with a history of SARS-CoV-2 infection during their pregnancy were surveyed for their preferences in nutritional supplementation and their profile compared with existing records from the institutional database. A cohort of 448 pregnant women with COVID-19 during 22 months of the pandemic was assembled, out of which 13.6% took a magnesium-only supplement, and 16.5% supplemented their diet with a combination of calcium, magnesium, and zinc. Around 60% of patients in the no-supplementation group had the SARS-CoV-2 anti-RBD lower than 500 U/mL, compared with 50% in those who took magnesium-based supplements. A quantity of magnesium >450 mg in the taken supplements determined higher levels of antibody titers after COVID-19. Low magnesium dosage (<450 mg) was an independent risk factor for a weak immune response (OR-1.25, p-value = 0.003). The observed findings suggest supplementing the nutritional intake of pregnant women with magnesium-based supplements to determine higher levels of SARS-CoV-2 anti-RBD antibodies, although causality remains unclear.
  • |*COVID-19[MESH]
  • |*Magnesium[MESH]
  • |Calcium[MESH]
  • |Calcium, Dietary[MESH]
  • |Cross-Sectional Studies[MESH]
  • |Dietary Supplements[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Immunity[MESH]
  • |Micronutrients[MESH]
  • |Pregnancy[MESH]
  • |Pregnancy Outcome[MESH]
  • |SARS-CoV-2[MESH]


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