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10.1089/ham.2021.0158

http://scihub22266oqcxt.onion/10.1089/ham.2021.0158
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35394893!ä!35394893

suck abstract from ncbi


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pmid35394893      High+Alt+Med+Biol 2022 ; 23 (3): 286-290
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  • Treatment of Focal and Segmental Glomerulosclerosis Secondary to High Altitude Polycythemia with Acetazolamide #MMPMID35394893
  • Vizcarra-Vizcarra CA; Chavez-Velazquez E; Asato-Higa C; Hurtado-Arestegui A
  • High Alt Med Biol 2022[Sep]; 23 (3): 286-290 PMID35394893show ga
  • Vizcarra-Vizcarra, Cristhian A., Eduardo Chavez-Velazquez, Carmen Asato-Higa, and Abdias Hurtado-Arestegui. Treatment of focal and segmental glomerulosclerosis secondary to high altitude polycythemia with acetazolamide. High Alt Med Biol. 23:286-290, 2022.-Focal segmental glomerulosclerosis (FSGS) is a morphological pattern, caused by glomerular injury and is the leading cause of nephrotic syndrome in adults. We present the case of a 59-year-old female patient, resident of a high-altitude city (3,824 m), who had polycythemia and nephrotic syndrome. A renal biopsy was performed, and the findings were compatible with FSGS. The patient received phlebotomy 500 ml three times, which reduced, partially, the hemoglobin concentration. However, she had refractory proteinuria, despite the use of enalapril and spironolactone. We observed that proteinuria worsened with the increase in hemoglobin levels. So, she was treated with acetazolamide 250 mg bid for 4 months, which reduced proteinuria and hemoglobin. During the coronavirus disease 2019 (COVID-19) pandemic, the patient did not take acetazolamide and again, she had an increase in hemoglobin and proteinuria levels. We conclude that acetazolamide may be an effective treatment in FSGS due to high altitude polycythemia.
  • |*Altitude Sickness/complications/drug therapy[MESH]
  • |*COVID-19[MESH]
  • |*Glomerulosclerosis, Focal Segmental/complications/etiology[MESH]
  • |*Nephrotic Syndrome/complications/pathology[MESH]
  • |*Polycythemia/complications/etiology[MESH]
  • |Acetazolamide/therapeutic use[MESH]
  • |Adult[MESH]
  • |Altitude[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Middle Aged[MESH]


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