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10.1016/j.mbplus.2022.100106 http://scihub22266oqcxt.onion/10.1016/j.mbplus.2022.100106 35392182!8981764!35392182     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Matrix+Biol+Plus 2022 ; 14 (ä): 100106 Nephropedia Template TP {{tp|p=35392182|t=2022. The endothelial glycocalyx in critical illness: A pediatric perspective |pdf=|usr=}}{{35392182}} gab.com Text The endothelial glycocalyx in critical illness: A pediatric perspective JO: Matrix Biol Plus http://www.kidney.de/pget.php?&tw=1&pmid=35392182 #FOAvip The vascular endothelium is the interface between circulating blood and end organs and thus has a critical role in preserving organ function. The endothelium is lined by a glycan-rich glycocalyx that uniquely contributes to endothelial function through its regulation of leukocyte and platelet interactions with the vessel wall, vascular permeability, coagulation, and vasoreactivity. Degradation of the endothelial glycocalyx can thus promote vascular dysfunction, inflammation propagation, and organ injury. The endothelial glycocalyx and its role in vascular pathophysiology has gained increasing attention over the last decade. While studies characterizing vascular glycocalyx injury and its downstream consequences in a host of adult human diseases and in animal models has burgeoned, studies evaluating glycocalyx damage in pediatric diseases are relatively few. As children have unique physiology that differs from adults, significant knowledge gaps remain in our understanding of the causes and effects of endothelial glycocalyx disintegrity in pediatric critical illness. In this narrative literature overview, we offer a unique perspective on the role of the endothelial glycocalyx in pediatric critical illness, drawing from adult and preclinical data in addition to pediatric clinical experience to elucidate how marked derangement of the endothelial surface layer may contribute to aberrant vascular biology in children. By calling attention to this nascent field, we hope to increase research efforts to address important knowledge gaps in pediatric vascular biology that may inform the development of novel therapeutic strategies. Twit Text FOAVip The endothelial glycocalyx in critical illness: A pediatric perspective ????Matrix Biol Plus http://www.kidney.de/pget.php?&tw=1&pmid=35392182 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35392182 #FOAvip English Wikipedia <ref>{{Cite pmid|35392182}}</ref> The endothelial glycocalyx in critical illness: A pediatric perspective #MMPMID35392182 Richter RP; Payne GA; Ambalavanan N; Gaggar A; Richter JR Matrix Biol Plus 2022[Jun]; 14 (ä): 100106 PMID35392182show ga The vascular endothelium is the interface between circulating blood and end organs and thus has a critical role in preserving organ function. The endothelium is lined by a glycan-rich glycocalyx that uniquely contributes to endothelial function through its regulation of leukocyte and platelet interactions with the vessel wall, vascular permeability, coagulation, and vasoreactivity. Degradation of the endothelial glycocalyx can thus promote vascular dysfunction, inflammation propagation, and organ injury. The endothelial glycocalyx and its role in vascular pathophysiology has gained increasing attention over the last decade. While studies characterizing vascular glycocalyx injury and its downstream consequences in a host of adult human diseases and in animal models has burgeoned, studies evaluating glycocalyx damage in pediatric diseases are relatively few. As children have unique physiology that differs from adults, significant knowledge gaps remain in our understanding of the causes and effects of endothelial glycocalyx disintegrity in pediatric critical illness. In this narrative literature overview, we offer a unique perspective on the role of the endothelial glycocalyx in pediatric critical illness, drawing from adult and preclinical data in addition to pediatric clinical experience to elucidate how marked derangement of the endothelial surface layer may contribute to aberrant vascular biology in children. By calling attention to this nascent field, we hope to increase research efforts to address important knowledge gaps in pediatric vascular biology that may inform the development of novel therapeutic strategies. äThe endothelial glycocalyx in critical illness: A pediatric perspectiv(epmc).pdf DeepDyve Pubget Overpricing