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10.3389/fimmu.2022.842150

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suck abstract from ncbi


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pmid35386702      Front+Immunol 2022 ; 13 (ä): 842150
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  • Plasma Cytokine Atlas Reveals the Importance of TH2 Polarization and Interferons in Predicting COVID-19 Severity and Survival #MMPMID35386702
  • Gibellini L; De Biasi S; Meschiari M; Gozzi L; Paolini A; Borella R; Mattioli M; Lo Tartaro D; Fidanza L; Neroni A; Busani S; Girardis M; Guaraldi G; Mussini C; Cozzi-Lepri A; Cossarizza A
  • Front Immunol 2022[]; 13 (ä): 842150 PMID35386702show ga
  • Although it is now widely accepted that host inflammatory response contributes to COVID-19 immunopathogenesis, the pathways and mechanisms driving disease severity and clinical outcome remain poorly understood. In the effort to identify key soluble mediators that characterize life-threatening COVID-19, we quantified 62 cytokines, chemokines and other factors involved in inflammation and immunity in plasma samples, collected at hospital admission, from 80 hospitalized patients with severe COVID-19 disease who were stratified on the basis of clinical outcome (mechanical ventilation or death by day 28). Our data confirm that age, as well as neutrophilia, lymphocytopenia, procalcitonin, D-dimer and lactate dehydrogenase are strongly associated with the risk of fatal COVID-19. In addition, we found that cytokines related to TH2 regulations (IL-4, IL-13, IL-33), cell metabolism (lep, lep-R) and interferons (IFNalpha, IFNbeta, IFNgamma) were also predictive of life-threatening COVID-19.
  • |*COVID-19[MESH]
  • |*Cytokines[MESH]
  • |Chemokines[MESH]
  • |Humans[MESH]
  • |Interferons[MESH]


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