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10.1172/jci.insight.154183 http://scihub22266oqcxt.onion/10.1172/jci.insight.154183 35380990!9090263!35380990     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JCI+Insight 2022 ; 7 (9): ä Nephropedia Template TP {{tp|p=35380990|t=2022. Functional reprogramming of monocytes in patients with acute and convalescent severe COVID-19 |pdf=|usr=}}{{35380990}} gab.com Text Functional reprogramming of monocytes in patients with acute and convalescent severe COVID-19 JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=35380990 #FOAvip Severe COVID-19 disease is associated with dysregulation of the myeloid compartment during acute infection. Survivors frequently experience long-lasting sequelae, but little is known about the eventual persistence of this immune alteration. Herein, we evaluated TLR-induced cytokine responses in a cohort of mild to critical patients during acute or convalescent phases (n = 97). In the acute phase, we observed impaired cytokine production by monocytes in the patients with the most severe COVID-19. This capacity was globally restored in convalescent patients. However, we observed increased responsiveness to TLR1/2 ligation in patients who recovered from severe disease, indicating that these cells display distinct functional properties at the different stages of the disease. In patients with acute severe COVID-19, we identified a specific transcriptomic and epigenomic state in monocytes that can account for their functional refractoriness. The molecular profile of monocytes from recovering patients was distinct and characterized by increased chromatin accessibility at activating protein 1 (AP1) and MAF loci. These results demonstrate that severe COVID-19 infection has a profound impact on the differentiation status and function of circulating monocytes, during both the acute and the convalescent phases, in a completely distinct manner. This could have important implications for our understanding of short- and long-term COVID-19-related morbidity. Twit Text FOAVip Functional reprogramming of monocytes in patients with acute and convalescent severe COVID-19 ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=35380990 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35380990 #FOAvip English Wikipedia <ref>{{Cite pmid|35380990}}</ref> Functional reprogramming of monocytes in patients with acute and convalescent severe COVID-19 #MMPMID35380990 Brauns E; Azouz A; Grimaldi D; Xiao H; Thomas S; Nguyen M; Olislagers V; Vu Duc I; Orte Cano C; Del Marmol V; Pannus P; Libert F; Saussez S; Dauby N; Das J; Marchant A; Goriely S JCI Insight 2022[Apr]; 7 (9): ä PMID35380990show ga Severe COVID-19 disease is associated with dysregulation of the myeloid compartment during acute infection. Survivors frequently experience long-lasting sequelae, but little is known about the eventual persistence of this immune alteration. Herein, we evaluated TLR-induced cytokine responses in a cohort of mild to critical patients during acute or convalescent phases (n = 97). In the acute phase, we observed impaired cytokine production by monocytes in the patients with the most severe COVID-19. This capacity was globally restored in convalescent patients. However, we observed increased responsiveness to TLR1/2 ligation in patients who recovered from severe disease, indicating that these cells display distinct functional properties at the different stages of the disease. In patients with acute severe COVID-19, we identified a specific transcriptomic and epigenomic state in monocytes that can account for their functional refractoriness. The molecular profile of monocytes from recovering patients was distinct and characterized by increased chromatin accessibility at activating protein 1 (AP1) and MAF loci. These results demonstrate that severe COVID-19 infection has a profound impact on the differentiation status and function of circulating monocytes, during both the acute and the convalescent phases, in a completely distinct manner. This could have important implications for our understanding of short- and long-term COVID-19-related morbidity. |*COVID-19[MESH] |Cytokines/metabolism[MESH] |Disease Progression[MESH] |Humans[MESH] |Monocytes/metabolism[MESH]Functional reprogramming of monocytes in patients with acute and conva(epmc).pdf DeepDyve Pubget Overpricing