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10.4049/jimmunol.2101099

http://scihub22266oqcxt.onion/10.4049/jimmunol.2101099
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35379747!9012677!35379747
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suck abstract from ncbi


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pmid35379747      J+Immunol 2022 ; 208 (8): 1968-1977
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  • Characterization of Altered Gene Expression and Histone Methylation in Peripheral Blood Mononuclear Cells Regulating Inflammation in COVID-19 Patients #MMPMID35379747
  • Yang X; Rutkovsky AC; Zhou J; Zhong Y; Reese J; Schnell T; Albrecht H; Owens WB; Nagarkatti PS; Nagarkatti M
  • J Immunol 2022[Apr]; 208 (8): 1968-1977 PMID35379747show ga
  • The pandemic of COVID-19 has caused >5 million deaths in the world. One of the leading causes of the severe form of COVID-19 is the production of massive amounts of proinflammatory cytokines. Epigenetic mechanisms, such as histone/DNA methylation, miRNA, and long noncoding RNA, are known to play important roles in the regulation of inflammation. In this study, we investigated if hospitalized COVID-19 patients exhibit alterations in epigenetic pathways in their PBMCs. We also compared gene expression profiles between healthy controls and COVID-19 patients. Despite individual variations, the expressions of many inflammation-related genes, such as arginase 1 and IL-1 receptor 2, were significantly upregulated in COVID-19 patients. We also found the expressions of coagulation-related genes Von Willebrand factor and protein S were altered in COVID-19 patients. The expression patterns of some genes, such as IL-1 receptor 2, correlated with their histone methylation marks. Pathway analysis indicated that most of those dysregulated genes were in the TGF-beta, IL-1b, IL-6, and IL-17 pathways. A targeting pathway revealed that the majority of those altered genes were targets of dexamethasone, which is an approved drug for COVID-19 treatment. We also found that the expression of bone marrow kinase on chromosome X, a member of TEC family kinases, was increased in the PBMCs of COVID-19 patients. Interestingly, some inhibitors of TEC family kinases have been used to treat COVID-19. Overall, this study provides important information toward identifying potential biomarkers and therapeutic targets for COVID-19 disease.
  • |*COVID-19 Drug Treatment[MESH]
  • |*COVID-19/genetics/metabolism[MESH]
  • |*Inflammation/genetics/metabolism[MESH]
  • |*Leukocytes, Mononuclear/metabolism[MESH]
  • |DNA Methylation[MESH]
  • |Epigenesis, Genetic/physiology[MESH]
  • |Gene Expression[MESH]
  • |Histones/metabolism[MESH]
  • |Humans[MESH]
  • |Receptors, Interleukin-1/metabolism[MESH]


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