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10.3389/fimmu.2022.807934 http://scihub22266oqcxt.onion/10.3389/fimmu.2022.807934 35371058!8965558!35371058     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2022 ; 13 (ä): 807934 Nephropedia Template TP {{tp|p=35371058|t=2022. The COVID Complex: A Review of Platelet Activation and Immune Complexes in COVID-19 |pdf=|usr=}}{{35371058}} gab.com Text The COVID Complex: A Review of Platelet Activation and Immune Complexes in COVID-19 JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=35371058 #FOAvip Coronavirus disease 2019 (COVID-19) is a highly prothrombotic viral infection that primarily manifests as an acute respiratory syndrome. However, critically ill COVID-19 patients will often develop venous thromboembolism with associated increases in morbidity and mortality. The cause for this prothrombotic state is unclear but is likely related to platelet hyperactivation. In this review, we summarize the current evidence surrounding COVID-19 thrombosis and platelet hyperactivation. We highlight the fact that several studies have identified a soluble factor in COVID-19 patient plasma that is capable of altering platelet phenotype in vitro. Furthermore, this soluble factor appears to be an immune complex, which may be composed of COVID-19 Spike protein and related antibodies. We suggest that these Spike-specific immune complexes contribute to COVID-19 platelet activation and thrombosis in a manner similar to heparin-induced thrombocytopenia. Understanding this underlying pathobiology will be critical for advancement of future research and therapeutic options. Twit Text FOAVip The COVID Complex: A Review of Platelet Activation and Immune Complexes in COVID-19 ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=35371058 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35371058 #FOAvip English Wikipedia <ref>{{Cite pmid|35371058}}</ref> The COVID Complex: A Review of Platelet Activation and Immune Complexes in COVID-19 #MMPMID35371058 Jevtic SD; Nazy I Front Immunol 2022[]; 13 (ä): 807934 PMID35371058show ga Coronavirus disease 2019 (COVID-19) is a highly prothrombotic viral infection that primarily manifests as an acute respiratory syndrome. However, critically ill COVID-19 patients will often develop venous thromboembolism with associated increases in morbidity and mortality. The cause for this prothrombotic state is unclear but is likely related to platelet hyperactivation. In this review, we summarize the current evidence surrounding COVID-19 thrombosis and platelet hyperactivation. We highlight the fact that several studies have identified a soluble factor in COVID-19 patient plasma that is capable of altering platelet phenotype in vitro. Furthermore, this soluble factor appears to be an immune complex, which may be composed of COVID-19 Spike protein and related antibodies. We suggest that these Spike-specific immune complexes contribute to COVID-19 platelet activation and thrombosis in a manner similar to heparin-induced thrombocytopenia. Understanding this underlying pathobiology will be critical for advancement of future research and therapeutic options. |*COVID-19[MESH] |*Thrombosis/etiology[MESH] |Antigen-Antibody Complex/adverse effects[MESH] |Humans[MESH] |Platelet Activation[MESH] |Platelet Factor 4[MESH]The COVID Complex: A Review of Platelet Activation and Immune Complexe(epmc).pdf DeepDyve Pubget Overpricing