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10.1007/s00430-022-00734-9 http://scihub22266oqcxt.onion/10.1007/s00430-022-00734-9 35366686!8976456!35366686     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Med+Microbiol+Immunol 2023 ; 212 (2): 125-131 Nephropedia Template TP {{tp|p=35366686|t=2023. Interferon antagonists encoded by SARS-CoV-2 at a glance |pdf=|usr=}}{{35366686}} gab.com Text Interferon antagonists encoded by SARS-CoV-2 at a glance JO: Med Microbiol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=35366686 #FOAvip The innate immune system is a powerful barrier against invading pathogens. Interferons (IFNs) are a major part of the cytokine-mediated anti-viral innate immune response. After recognition of a pathogen by immune sensors, signaling cascades are activated that culminate in the release of IFNs. These activate cells in an autocrine or paracrine fashion eventually setting cells in an anti-viral state via upregulation of hundreds of interferon-stimulated genes (ISGs). To evade the anti-viral effect of the IFN system, successful viruses like the pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolved strategies to counteract both IFN induction and signaling. In fact, more than half of the about 30 proteins encoded by SARS-CoV-2 target the IFN system at multiple levels to escape IFN-mediated restriction. Here, we review recent insights into the molecular mechanisms used by SARS-CoV-2 proteins to suppress IFN production and the establishment of an anti-viral state. Twit Text FOAVip Interferon antagonists encoded by SARS-CoV-2 at a glance ????Med Microbiol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=35366686 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35366686 #FOAvip English Wikipedia <ref>{{Cite pmid|35366686}}</ref> Interferon antagonists encoded by SARS-CoV-2 at a glance #MMPMID35366686 Lee JH; Koepke L; Kirchhoff F; Sparrer KMJ Med Microbiol Immunol 2023[Apr]; 212 (2): 125-131 PMID35366686show ga The innate immune system is a powerful barrier against invading pathogens. Interferons (IFNs) are a major part of the cytokine-mediated anti-viral innate immune response. After recognition of a pathogen by immune sensors, signaling cascades are activated that culminate in the release of IFNs. These activate cells in an autocrine or paracrine fashion eventually setting cells in an anti-viral state via upregulation of hundreds of interferon-stimulated genes (ISGs). To evade the anti-viral effect of the IFN system, successful viruses like the pandemic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) evolved strategies to counteract both IFN induction and signaling. In fact, more than half of the about 30 proteins encoded by SARS-CoV-2 target the IFN system at multiple levels to escape IFN-mediated restriction. Here, we review recent insights into the molecular mechanisms used by SARS-CoV-2 proteins to suppress IFN production and the establishment of an anti-viral state. |*COVID-19[MESH] |*Interferons/genetics[MESH] |Antiviral Agents/pharmacology/therapeutic use[MESH] |Humans[MESH] |Immunity, Innate[MESH]Interferon antagonists encoded by SARS-CoV-2 at a glance (epmc).pdf DeepDyve Pubget Overpricing