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10.1097/PAI.0000000000001023

http://scihub22266oqcxt.onion/10.1097/PAI.0000000000001023
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suck abstract from ncbi


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pmid35363626      Appl+Immunohistochem+Mol+Morphol 2022 ; 30 (5): 350-357
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  • Patterns of Inflammatory Cell Infiltration and Expression of STAT6 in the Lungs of Patients With COVID-19: An Autopsy Study #MMPMID35363626
  • Cao W; Birkenbach M; Chen S
  • Appl Immunohistochem Mol Morphol 2022[May]; 30 (5): 350-357 PMID35363626show ga
  • BACKGROUND: Severe acute respiratory syndrome coronavirus 2 causes diffuse alveolar damage (DAD), lymphocyte infiltration in the lungs and a cytokine storm. In this study we examined inflammatory cell infiltrates and the expression of signal transducer and activator of transcription (STAT) 6 in the lungs of patients with coronavirus disease 2019 (COVID-19). METHODS: Eighteen COVID-19 autopsy cases, 9 non-COVID cases with DAD, and 11 controls without lung diseases were included. Immunostainings for STAT6, CD3, CD4, CD8, CD68, and broad-spectrum keratins were performed. RESULTS: The average age of COVID-19 patients was 64.4+/-2.1 years. The disease duration was 7 to 53 days. The number of pneumocytes, macrophages or CD3+ T cells was significantly increased in the lungs of patients with COVID-19. Patients' age above 67 years, blood troponin levels >0.2 ng/mL, platelet count >100x109/L, lung macrophages >130/high-power field (HPF), CD3+ T cells >145/HPF, CD8+ T cells <30/HPF, and CD8/CD4 ratio <1 were associated with shorter survival duration after onset of symptoms. In addition, STAT6 staining was much stronger in pneumocytes and lymphocytes in the lungs of patients with COVID-19 than non-COVID DAD patients or controls. CONCLUSION: Older age, high blood troponin level and platelet count, more macrophages and fewer CD8+ T cells in the lungs of COVID-19 were associated with poorer outcome. STAT6 expression was increased in pneumocytes and lymphocytes in the lungs of patients with COVID-19, implying a role of STAT6 in cytokine storms.
  • |*COVID-19[MESH]
  • |Aged[MESH]
  • |Autopsy[MESH]
  • |Humans[MESH]
  • |Lung[MESH]
  • |Middle Aged[MESH]
  • |SARS-CoV-2[MESH]
  • |STAT6 Transcription Factor[MESH]


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