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10.15252/emmm.202114844 http://scihub22266oqcxt.onion/10.15252/emmm.202114844 35362189!9081906!35362189     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Mol+Med 2022 ; 14 (5): e14844 Nephropedia Template TP {{tp|p=35362189|t=2022. SARS-CoV-2 spike spurs intestinal inflammation via VEGF production in enterocytes |pdf=|usr=}}{{35362189}} gab.com Text SARS-CoV-2 spike spurs intestinal inflammation via VEGF production in enterocytes JO: EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=35362189 #FOAvip Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can cause gastrointestinal (GI) symptoms that often correlate with the severity of COVID-19. Here, we explored the pathogenesis underlying the intestinal inflammation in COVID-19. Plasma VEGF level was particularly elevated in patients with GI symptoms and significantly correlated with intestinal edema and disease progression. Through an animal model mimicking intestinal inflammation upon stimulation with SARS-CoV-2 spike protein, we further revealed that VEGF was over-produced in the duodenum prior to its ascent in the circulation. Mechanistically, SARS-CoV-2 spike promoted VEGF production through activating the Ras-Raf-MEK-ERK signaling in enterocytes, but not in endothelium, and inducing permeability and inflammation. Blockage of the ERK/VEGF axis was able to rescue vascular permeability and alleviate intestinal inflammation in vivo. These findings provide a mechanistic explanation and therapeutic targets for the GI symptoms of COVID-19. Twit Text FOAVip SARS-CoV-2 spike spurs intestinal inflammation via VEGF production in enterocytes ????EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=35362189 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35362189 #FOAvip English Wikipedia <ref>{{Cite pmid|35362189}}</ref> SARS-CoV-2 spike spurs intestinal inflammation via VEGF production in enterocytes #MMPMID35362189 Zeng FM; Li YW; Deng ZH; He JZ; Li W; Wang L; Lyu T; Li Z; Mei C; Yang M; Dong Y; Jiang GM; Li X; Huang X; Xiao F; Liu Y; Shan H; He H EMBO Mol Med 2022[May]; 14 (5): e14844 PMID35362189show ga Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can cause gastrointestinal (GI) symptoms that often correlate with the severity of COVID-19. Here, we explored the pathogenesis underlying the intestinal inflammation in COVID-19. Plasma VEGF level was particularly elevated in patients with GI symptoms and significantly correlated with intestinal edema and disease progression. Through an animal model mimicking intestinal inflammation upon stimulation with SARS-CoV-2 spike protein, we further revealed that VEGF was over-produced in the duodenum prior to its ascent in the circulation. Mechanistically, SARS-CoV-2 spike promoted VEGF production through activating the Ras-Raf-MEK-ERK signaling in enterocytes, but not in endothelium, and inducing permeability and inflammation. Blockage of the ERK/VEGF axis was able to rescue vascular permeability and alleviate intestinal inflammation in vivo. These findings provide a mechanistic explanation and therapeutic targets for the GI symptoms of COVID-19. |*COVID-19[MESH] |*SARS-CoV-2[MESH] |Animals[MESH] |Enterocytes/metabolism[MESH] |Humans[MESH] |Inflammation/metabolism[MESH] |Spike Glycoprotein, Coronavirus[MESH]SARS-CoV-2 spike spurs intestinal inflammation via VEGF production in (epmc).pdf DeepDyve Pubget Overpricing