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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Leukoc+Biol 2022 ; 112 (1): 23-29 Nephropedia Template TP
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Loss of mitochondrial membrane potential (DeltaPsi(m) ) in leucocytes as post-COVID-19 sequelae #MMPMID35355308
Diaz-Resendiz KJG; Benitez-Trinidad AB; Covantes-Rosales CE; Toledo-Ibarra GA; Ortiz-Lazareno PC; Giron-Perez DA; Bueno-Duran AY; Perez-Diaz DA; Barcelos-Garcia RG; Giron-Perez MI
J Leukoc Biol 2022[Jul]; 112 (1): 23-29 PMID35355308show ga
The mitochondrial membrane potential (DeltaPsi(m) ) is a parameter often used to determine mitochondrial function; therefore, it can be used to determine the integrity and functionality of cells. A decrement of DeltaPsi(m) is implicated in several inflammatory-related pathologies, such phenomena can be related to COVID-19 infection. The present work aimed to compare the DeltaPsi(m) in leucocytes (human PBMCs; HPBMC) isolated from healthy control (HC) subjects, patients with COVID-19 (C-19), recovered subjects at 40 +/- 13 (R1) and 335 +/- 20 (R2) days after infection (dai). Obtained data showed that DeltaPsi(m) decreased in HPBMC of subjects with C-19, R1, and R2 compared with HC. When analyzing the DeltaPsi(m) data by sex, in females, a significant decrease was observed in R1 and R2 groups versus HC. Regarding men, a significant decrease of DeltaPsi(m) was observed in R1, with respect to HC, contrary to R2 group, who reestablished this parameter. Obtained results suggest that the loss of DeltaPsi(m) could be related to the long-COVID.