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10.1371/journal.pgen.1010130 http://scihub22266oqcxt.onion/10.1371/journal.pgen.1010130 35353808!9000099!35353808     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Genet 2022 ; 18 (3): e1010130 Nephropedia Template TP {{tp|p=35353808|t=2022. RNA editing increases the nucleotide diversity of SARS-CoV-2 in human host cells |pdf=|usr=}}{{35353808}} gab.com Text RNA editing increases the nucleotide diversity of SARS-CoV-2 in human host cells JO: PLoS Genet http://www.kidney.de/pget.php?&tw=1&pmid=35353808 #FOAvip SARS-CoV-2 is a positive-sense, single-stranded RNA virus responsible for the COVID-19 pandemic. It remains unclear whether and to what extent the virus in human host cells undergoes RNA editing, a major RNA modification mechanism. Here we perform a robust bioinformatic analysis of metatranscriptomic data from multiple bronchoalveolar lavage fluid samples of COVID-19 patients, revealing an appreciable number of A-to-I RNA editing candidate sites in SARS-CoV-2. We confirm the enrichment of A-to-I RNA editing signals at these candidate sites through evaluating four characteristics specific to RNA editing: the inferred RNA editing sites exhibit (i) stronger ADAR1 binding affinity predicted by a deep-learning model built from ADAR1 CLIP-seq data, (ii) decreased editing levels in ADAR1-inhibited human lung cells, (iii) local clustering patterns, and (iv) higher RNA secondary structure propensity. Our results have critical implications in understanding the evolution of SARS-CoV-2 as well as in COVID-19 research, such as phylogenetic analysis and vaccine development. Twit Text FOAVip RNA editing increases the nucleotide diversity of SARS-CoV-2 in human host cells ????PLoS Genet http://www.kidney.de/pget.php?&tw=1&pmid=35353808 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35353808 #FOAvip English Wikipedia <ref>{{Cite pmid|35353808}}</ref> RNA editing increases the nucleotide diversity of SARS-CoV-2 in human host cells #MMPMID35353808 Peng X; Luo Y; Li H; Guo X; Chen H; Ji X; Liang H PLoS Genet 2022[Mar]; 18 (3): e1010130 PMID35353808show ga SARS-CoV-2 is a positive-sense, single-stranded RNA virus responsible for the COVID-19 pandemic. It remains unclear whether and to what extent the virus in human host cells undergoes RNA editing, a major RNA modification mechanism. Here we perform a robust bioinformatic analysis of metatranscriptomic data from multiple bronchoalveolar lavage fluid samples of COVID-19 patients, revealing an appreciable number of A-to-I RNA editing candidate sites in SARS-CoV-2. We confirm the enrichment of A-to-I RNA editing signals at these candidate sites through evaluating four characteristics specific to RNA editing: the inferred RNA editing sites exhibit (i) stronger ADAR1 binding affinity predicted by a deep-learning model built from ADAR1 CLIP-seq data, (ii) decreased editing levels in ADAR1-inhibited human lung cells, (iii) local clustering patterns, and (iv) higher RNA secondary structure propensity. Our results have critical implications in understanding the evolution of SARS-CoV-2 as well as in COVID-19 research, such as phylogenetic analysis and vaccine development. |*COVID-19/genetics[MESH] |*SARS-CoV-2/genetics[MESH] |Adenosine Deaminase/metabolism[MESH] |Humans[MESH] |Nucleotides/metabolism[MESH] |Pandemics[MESH] |Phylogeny[MESH] |RNA Editing/genetics[MESH]RNA editing increases the nucleotide diversity of SARS-CoV-2 in human (epmc).pdf DeepDyve Pubget Overpricing