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10.1016/j.isci.2022.104136 http://scihub22266oqcxt.onion/10.1016/j.isci.2022.104136 35342878!8937612!35342878     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       iScience 2022 ; 25 (4): 104136 Nephropedia Template TP {{tp|p=35342878|t=2022. Identified human breast milk compositions effectively inhibit SARS-CoV-2 and variants infection and replication |pdf=|usr=}}{{35342878}} gab.com Text Identified human breast milk compositions effectively inhibit SARS-CoV-2 and variants infection and replication JO: iScience http://www.kidney.de/pget.php?&tw=1&pmid=35342878 #FOAvip The global pandemic of COVID-19 caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection confers great threat to public health. Human breast milk is a complex nutritional composition to nourish infants and protect them from different kinds of infectious diseases including COVID-19. Here, we identified that lactoferrin (LF), mucin1 (MUC1), and alpha-lactalbumin (alpha-LA) from human breast milk inhibit SARS-CoV-2 infection using a SARS-CoV-2 pseudovirus system and transcription and replication-competent SARS-CoV-2 virus-like-particles (trVLP). In addition, LF and MUC1 inhibited multiple steps including viral attachment, entry, and postentry replication, whereas alpha-LA inhibited viral attachment and entry. Importantly, LF, MUC1, and alpha-LA possess potent antiviral activities toward variants such as B.1.1.7 (alpha), B.1.351 (beta), P.1 (gamma), and B.1.617.1 (kappa). Taken together, our study provides evidence that human breast milk components (LF, MUC1, and alpha-LA) are promising antiviral and potential therapeutic candidates warranting further development for treating COVID-19. Twit Text FOAVip Identified human breast milk compositions effectively inhibit SARS-CoV-2 and variants infection and replication ????iScience http://www.kidney.de/pget.php?&tw=1&pmid=35342878 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35342878 #FOAvip English Wikipedia <ref>{{Cite pmid|35342878}}</ref> Identified human breast milk compositions effectively inhibit SARS-CoV-2 and variants infection and replication #MMPMID35342878 Lai X; Yu Y; Xian W; Ye F; Ju X; Luo Y; Dong H; Zhou YH; Tan W; Zhuang H; Li T; Liu X; Ding Q; Xiang K iScience 2022[Apr]; 25 (4): 104136 PMID35342878show ga The global pandemic of COVID-19 caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection confers great threat to public health. Human breast milk is a complex nutritional composition to nourish infants and protect them from different kinds of infectious diseases including COVID-19. Here, we identified that lactoferrin (LF), mucin1 (MUC1), and alpha-lactalbumin (alpha-LA) from human breast milk inhibit SARS-CoV-2 infection using a SARS-CoV-2 pseudovirus system and transcription and replication-competent SARS-CoV-2 virus-like-particles (trVLP). In addition, LF and MUC1 inhibited multiple steps including viral attachment, entry, and postentry replication, whereas alpha-LA inhibited viral attachment and entry. Importantly, LF, MUC1, and alpha-LA possess potent antiviral activities toward variants such as B.1.1.7 (alpha), B.1.351 (beta), P.1 (gamma), and B.1.617.1 (kappa). Taken together, our study provides evidence that human breast milk components (LF, MUC1, and alpha-LA) are promising antiviral and potential therapeutic candidates warranting further development for treating COVID-19. äIdentified human breast milk compositions effectively inhibit SARS-CoV(epmc).pdf DeepDyve Pubget Overpricing