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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Mol+Cell+Cardiol 2022 ; 167 (ä): 92-96 Nephropedia Template TP
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Endothelin-1 is increased in the plasma of patients hospitalised with Covid-19 #MMPMID35339512
Abraham GR; Kuc RE; Althage M; Greasley PJ; Ambery P; Maguire JJ; Wilkinson IB; Hoole SP; Cheriyan J; Davenport AP
J Mol Cell Cardiol 2022[Jun]; 167 (ä): 92-96 PMID35339512show ga
Virus induced endothelial dysregulation is a well-recognised feature of severe Covid-19 infection. Endothelin-1 (ET-1) is the most highly expressed peptide in endothelial cells and a potent vasoconstrictor, thus representing a potential therapeutic target. ET-1 plasma levels were measured in a cohort of 194 Covid-19 patients stratified according to the clinical severity of their illness. Hospitalised patients, including those who died and those developing acute myocardial or kidney injury, had significantly elevated ET-1 plasma levels during the acute phase of infection. The results support the hypothesis that endothelin receptor antagonists may provide clinical benefit for certain Covid-19 patients.