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10.3390/v14030611 http://scihub22266oqcxt.onion/10.3390/v14030611 35337019!8951556!35337019     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35337019.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Viruses 2022 ; 14 (3): ä Nephropedia Template TP {{tp|p=35337019|t=2022. A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins |pdf=|usr=}}{{35337019}} gab.com Text A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=35337019 #FOAvip The novel coronavirus SARS-CoV-2 is responsible for the ongoing COVID-19 pandemic and has caused a major health and economic burden worldwide. Understanding how SARS-CoV-2 viral proteins behave in host cells can reveal underlying mechanisms of pathogenesis and assist in development of antiviral therapies. Here, the cellular impact of expressing SARS-CoV-2 viral proteins was studied by global proteomic analysis, and proximity biotinylation (BioID) was used to map the SARS-CoV-2 virus-host interactome in human lung cancer-derived cells. Functional enrichment analyses revealed previously reported and unreported cellular pathways that are associated with SARS-CoV-2 proteins. We have established a website to host the proteomic data to allow for public access and continued analysis of host-viral protein associations and whole-cell proteomes of cells expressing the viral-BioID fusion proteins. Furthermore, we identified 66 high-confidence interactions by comparing this study with previous reports, providing a strong foundation for future follow-up studies. Finally, we cross-referenced candidate interactors with the CLUE drug library to identify potential therapeutics for drug-repurposing efforts. Collectively, these studies provide a valuable resource to uncover novel SARS-CoV-2 biology and inform development of antivirals. Twit Text FOAVip A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=35337019 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35337019 #FOAvip English Wikipedia <ref>{{Cite pmid|35337019}}</ref> A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins #MMPMID35337019 May DG; Martin-Sancho L; Anschau V; Liu S; Chrisopulos RJ; Scott KL; Halfmann CT; Diaz Pena R; Pratt D; Campos AR; Roux KJ Viruses 2022[Mar]; 14 (3): ä PMID35337019show ga The novel coronavirus SARS-CoV-2 is responsible for the ongoing COVID-19 pandemic and has caused a major health and economic burden worldwide. Understanding how SARS-CoV-2 viral proteins behave in host cells can reveal underlying mechanisms of pathogenesis and assist in development of antiviral therapies. Here, the cellular impact of expressing SARS-CoV-2 viral proteins was studied by global proteomic analysis, and proximity biotinylation (BioID) was used to map the SARS-CoV-2 virus-host interactome in human lung cancer-derived cells. Functional enrichment analyses revealed previously reported and unreported cellular pathways that are associated with SARS-CoV-2 proteins. We have established a website to host the proteomic data to allow for public access and continued analysis of host-viral protein associations and whole-cell proteomes of cells expressing the viral-BioID fusion proteins. Furthermore, we identified 66 high-confidence interactions by comparing this study with previous reports, providing a strong foundation for future follow-up studies. Finally, we cross-referenced candidate interactors with the CLUE drug library to identify potential therapeutics for drug-repurposing efforts. Collectively, these studies provide a valuable resource to uncover novel SARS-CoV-2 biology and inform development of antivirals. |*COVID-19[MESH] |*SARS-CoV-2[MESH] |Biotinylation[MESH] |Humans[MESH] |Pandemics[MESH]A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins (epmc).pdf DeepDyve Pubget Overpricing