Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3390/v14030515 http://scihub22266oqcxt.onion/10.3390/v14030515 35336922!8955556!35336922     free     free     free       Viruses 2022 ; 14 (3): ä Nephropedia Template TP {{tp|p=35336922|t=2022. Multiorgan and Vascular Tropism of SARS-CoV-2 |pdf=|usr=}}{{35336922}} gab.com Text Multiorgan and Vascular Tropism of SARS-CoV-2 JO: Viruses http://www.kidney.de/pget.php?&tw=1&pmid=35336922 #FOAvip Although the respiratory tract is the main target of SARS-CoV-2, other tissues and organs are permissive to the infection. In this report, we investigated this wide-spectrum tropism by studying the SARS-CoV-2 genetic intra-host variability in multiple tissues. The virological and histological investigation of multiple specimens from a post-mortem COVID-19 patient was performed. SARS-CoV-2 genome was detected in several tissues, including the lower respiratory system, cardio-vascular biopsies, stomach, pancreas, adrenal gland, mediastinal ganglion and testicles. Subgenomic RNA transcripts were also detected, in favor of an active viral replication, especially in testicles. Ultra-deep sequencing allowed us to highlight several SARS-CoV-2 mutations according to tissue distribution. More specifically, mutations of the spike protein, i.e., V341A (18.3%), E654 (44%) and H655R (30.8%), were detected in the inferior vena cava. SARS-CoV-2 variability can contribute to heterogeneous distributions of viral quasispecies, which may affect the COVID-19 pathogeny. Twit Text FOAVip Multiorgan and Vascular Tropism of SARS-CoV-2 ????Viruses http://www.kidney.de/pget.php?&tw=1&pmid=35336922 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35336922 #FOAvip English Wikipedia <ref>{{Cite pmid|35336922}}</ref> Multiorgan and Vascular Tropism of SARS-CoV-2 #MMPMID35336922 Hartard C; Chaqroun A; Settembre N; Gauchotte G; Lefevre B; Marchand E; Mazeaud C; Nguyen DT; Martrille L; Koscinski I; Malikov S; Schvoerer E Viruses 2022[Mar]; 14 (3): ä PMID35336922show ga Although the respiratory tract is the main target of SARS-CoV-2, other tissues and organs are permissive to the infection. In this report, we investigated this wide-spectrum tropism by studying the SARS-CoV-2 genetic intra-host variability in multiple tissues. The virological and histological investigation of multiple specimens from a post-mortem COVID-19 patient was performed. SARS-CoV-2 genome was detected in several tissues, including the lower respiratory system, cardio-vascular biopsies, stomach, pancreas, adrenal gland, mediastinal ganglion and testicles. Subgenomic RNA transcripts were also detected, in favor of an active viral replication, especially in testicles. Ultra-deep sequencing allowed us to highlight several SARS-CoV-2 mutations according to tissue distribution. More specifically, mutations of the spike protein, i.e., V341A (18.3%), E654 (44%) and H655R (30.8%), were detected in the inferior vena cava. SARS-CoV-2 variability can contribute to heterogeneous distributions of viral quasispecies, which may affect the COVID-19 pathogeny. |*COVID-19[MESH] |*SARS-CoV-2/genetics[MESH] |Humans[MESH] |Tropism[MESH]Multiorgan and Vascular Tropism of SARS-CoV-2 (epmc).pdf DeepDyve Pubget Overpricing