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10.3390/ijms23063394 http://scihub22266oqcxt.onion/10.3390/ijms23063394 35328814!8949667!35328814     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35328814&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Int+J+Mol+Sci 2022 ; 23 (6): ? Nephropedia Template TP {{tp|p=35328814|t=2022. SARS-CoV-2 Proteins Interact with Alpha Synuclein and Induce Lewy Body-like Pathology In Vitro |pdf=|usr=}}{{35328814}} gab.com Text SARS-CoV-2 Proteins Interact with Alpha Synuclein and Induce Lewy Body-like Pathology In Vitro JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=35328814 #FOAvip Growing cases of patients reported have shown a potential relationship between (severe acute respiratory syndrome coronavirus 2) SARS-CoV-2 infection and Parkinson's disease (PD). However, it is unclear whether there is a molecular link between these two diseases. Alpha-synuclein (alpha-Syn), an aggregation-prone protein, is considered a crucial factor in PD pathology. In this study, bioinformatics analysis confirmed favorable binding affinity between alpha-Syn and SARS-CoV-2 spike (S) protein and nucleocapsid (N) protein, and direct interactions were further verified in HEK293 cells. The expression of alpha-Syn was upregulated and its aggregation was accelerated by S protein and N protein. It was noticed that SARS-CoV-2 proteins caused Lewy-like pathology in the presence of alpha-Syn overexpression. By confirming that SARS-CoV-2 proteins directly interact with alpha-Syn, our study offered new insights into the mechanism underlying the development of PD on the background of COVID-19. Twit Text FOAVip SARS-CoV-2 Proteins Interact with Alpha Synuclein and Induce Lewy Body-like Pathology In Vitro ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=35328814 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35328814 #FOAvip English Wikipedia <ref>{{Cite pmid|35328814}}</ref> SARS-CoV-2 Proteins Interact with Alpha Synuclein and Induce Lewy Body-like Pathology In Vitro #MMPMID35328814 Wu Z; Zhang X; Huang Z; Ma K Int J Mol Sci 2022[Mar]; 23 (6): ? PMID35328814show ga Growing cases of patients reported have shown a potential relationship between (severe acute respiratory syndrome coronavirus 2) SARS-CoV-2 infection and Parkinson's disease (PD). However, it is unclear whether there is a molecular link between these two diseases. Alpha-synuclein (alpha-Syn), an aggregation-prone protein, is considered a crucial factor in PD pathology. In this study, bioinformatics analysis confirmed favorable binding affinity between alpha-Syn and SARS-CoV-2 spike (S) protein and nucleocapsid (N) protein, and direct interactions were further verified in HEK293 cells. The expression of alpha-Syn was upregulated and its aggregation was accelerated by S protein and N protein. It was noticed that SARS-CoV-2 proteins caused Lewy-like pathology in the presence of alpha-Syn overexpression. By confirming that SARS-CoV-2 proteins directly interact with alpha-Syn, our study offered new insights into the mechanism underlying the development of PD on the background of COVID-19. |*COVID-19[MESH] |*Parkinson Disease/metabolism[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Lewy Bodies/metabolism[MESH] |SARS-CoV-2[MESH]SARS-CoV-2 Proteins Interact with Alpha Synuclein and Induce Lewy Body(epmc).pdf DeepDyve Pubget Overpricing