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10.1093/infdis/jiac060

http://scihub22266oqcxt.onion/10.1093/infdis/jiac060
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35323975!8992321!35323975
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suck abstract from ncbi


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pmid35323975      J+Infect+Dis 2022 ; 225 (10): 1688-1693
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  • Natural Killer Cell-Mediated Antibody-Dependent Cellular Cytotoxicity Against SARS-CoV-2 After Natural Infection Is More Potent Than After Vaccination #MMPMID35323975
  • Rieke GJ; van Bremen K; Bischoff J; ToVinh M; Monin MB; Schlabe S; Raabe J; Kaiser KM; Finnemann C; Odainic A; Kudaliyanage A; Latz E; Strassburg CP; Boesecke C; Schmidt SV; Kramer B; Rockstroh JK; Nattermann J
  • J Infect Dis 2022[May]; 225 (10): 1688-1693 PMID35323975show ga
  • We compared the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike-specific antibodies to induce natural killer cell-mediated antibody-dependent cellular cytotoxicity (ADCC) in patients with natural infection and vaccinated persons. Analyzing plasma samples from 39 coronavirus disease 2019 (COVID-19) patients and 11 vaccinated individuals, significant induction of ADCC could be observed over a period of more than 3 months in both vaccinated and recovered individuals. Although plasma antibody concentrations were lower in recovered patients, we found antibodies elicited by natural infection induced a significantly stronger ADCC response compared to those induced by vaccination, which may affect protection conferred by vaccination.
  • |*COVID-19/prevention & control[MESH]
  • |*SARS-CoV-2[MESH]
  • |Antibodies, Neutralizing[MESH]
  • |Antibodies, Viral[MESH]
  • |Antibody-Dependent Cell Cytotoxicity[MESH]
  • |Humans[MESH]
  • |Killer Cells, Natural[MESH]
  • |Spike Glycoprotein, Coronavirus[MESH]


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