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10.1038/s41431-022-01070-5 http://scihub22266oqcxt.onion/10.1038/s41431-022-01070-5 35322240!8940983!35322240     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35322240&cmd=llinks): Failed to open stream: HTTP request failed! 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Allelic imbalance of HLA-B expression in human lung cells infected with coronavirus and other respiratory viruses |pdf=|usr=}}{{35322240}} gab.com Text Allelic imbalance of HLA-B expression in human lung cells infected with coronavirus and other respiratory viruses JO: Eur J Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=35322240 #FOAvip The human leucocyte antigen (HLA) loci have been widely characterized to be associated with viral infectious diseases using either HLA allele frequency-based association or in silico predicted studies. However, there is less experimental evidence to link the HLA alleles with COVID-19 and other respiratory infectious diseases, particularly in the lung cells. To examine the role of HLA alleles in response to coronavirus and other respiratory viral infections in disease-relevant cells, we designed a two-stage study by integrating publicly accessible RNA-seq data sets, and performed allelic expression (AE) analysis on heterozygous HLA genotypes. We discovered an increased AE pattern accompanied with overexpression of HLA-B gene in SARS-CoV-2-infected human lung epithelial cells. Analysis of independent data sets verified the respiratory virus-induced AE of HLA-B gene in lung cells and tissues. The results were further experimentally validated in cultured lung cells infected with SARS-CoV-2. We further uncovered that the antiviral cytokine IFNbeta contribute to AE of the HLA-B gene in lung cells. Our analyses provide a new insight into allelic influence on the HLA expression in association with SARS-CoV-2 and other common viral infectious diseases. Twit Text FOAVip Allelic imbalance of HLA-B expression in human lung cells infected with coronavirus and other respiratory viruses ????Eur J Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=35322240 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35322240 #FOAvip English Wikipedia <ref>{{Cite pmid|35322240}}</ref> Allelic imbalance of HLA-B expression in human lung cells infected with coronavirus and other respiratory viruses #MMPMID35322240 Zhang Y; Sun Y; Zhu H; Hong H; Jiang J; Yao P; Liao H; Zhang Y Eur J Hum Genet 2022[Aug]; 30 (8): 922-929 PMID35322240show ga The human leucocyte antigen (HLA) loci have been widely characterized to be associated with viral infectious diseases using either HLA allele frequency-based association or in silico predicted studies. However, there is less experimental evidence to link the HLA alleles with COVID-19 and other respiratory infectious diseases, particularly in the lung cells. To examine the role of HLA alleles in response to coronavirus and other respiratory viral infections in disease-relevant cells, we designed a two-stage study by integrating publicly accessible RNA-seq data sets, and performed allelic expression (AE) analysis on heterozygous HLA genotypes. We discovered an increased AE pattern accompanied with overexpression of HLA-B gene in SARS-CoV-2-infected human lung epithelial cells. Analysis of independent data sets verified the respiratory virus-induced AE of HLA-B gene in lung cells and tissues. The results were further experimentally validated in cultured lung cells infected with SARS-CoV-2. We further uncovered that the antiviral cytokine IFNbeta contribute to AE of the HLA-B gene in lung cells. Our analyses provide a new insight into allelic influence on the HLA expression in association with SARS-CoV-2 and other common viral infectious diseases. |*COVID-19/genetics[MESH] |*SARS-CoV-2[MESH] |Allelic Imbalance[MESH] |HLA Antigens/genetics[MESH] |HLA-B Antigens/genetics[MESH] |Histocompatibility Antigens Class I/genetics[MESH] |Humans[MESH]Allelic imbalance of HLA-B expression in human lung cells infected wit(epmc).pdf DeepDyve Pubget Overpricing