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Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Eur+J+Hum+Genet 2022 ; 30 (8): 922-929 Nephropedia Template TP
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Allelic imbalance of HLA-B expression in human lung cells infected with coronavirus and other respiratory viruses #MMPMID35322240
Zhang Y; Sun Y; Zhu H; Hong H; Jiang J; Yao P; Liao H; Zhang Y
Eur J Hum Genet 2022[Aug]; 30 (8): 922-929 PMID35322240show ga
The human leucocyte antigen (HLA) loci have been widely characterized to be associated with viral infectious diseases using either HLA allele frequency-based association or in silico predicted studies. However, there is less experimental evidence to link the HLA alleles with COVID-19 and other respiratory infectious diseases, particularly in the lung cells. To examine the role of HLA alleles in response to coronavirus and other respiratory viral infections in disease-relevant cells, we designed a two-stage study by integrating publicly accessible RNA-seq data sets, and performed allelic expression (AE) analysis on heterozygous HLA genotypes. We discovered an increased AE pattern accompanied with overexpression of HLA-B gene in SARS-CoV-2-infected human lung epithelial cells. Analysis of independent data sets verified the respiratory virus-induced AE of HLA-B gene in lung cells and tissues. The results were further experimentally validated in cultured lung cells infected with SARS-CoV-2. We further uncovered that the antiviral cytokine IFNbeta contribute to AE of the HLA-B gene in lung cells. Our analyses provide a new insight into allelic influence on the HLA expression in association with SARS-CoV-2 and other common viral infectious diseases.
|*COVID-19/genetics[MESH]
|*SARS-CoV-2[MESH]
|Allelic Imbalance[MESH]
|HLA Antigens/genetics[MESH]
|HLA-B Antigens/genetics[MESH]
|Histocompatibility Antigens Class I/genetics[MESH]