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10.1016/j.celrep.2022.110549 http://scihub22266oqcxt.onion/10.1016/j.celrep.2022.110549 35320721!8939003!35320721     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35320721&cmd=llinks): Failed to open stream: HTTP request failed! 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Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defense |pdf=|usr=}}{{35320721}} gab.com Text Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defense JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=35320721 #FOAvip Host interferons (IFNs) powerfully restrict viruses through the action of several hundred IFN-stimulated gene (ISG) products, many of which remain uncharacterized. Here, using RNAi screening, we identify several ISG restriction factors with previously undescribed contributions to IFN-mediated defense. Notably, RABGAP1L, a Tre2/Bub2/Cdc16 (TBC)-domain-containing protein involved in regulation of small membrane-bound GTPases, robustly potentiates IFN action against influenza A viruses (IAVs). Functional studies reveal that the catalytically active TBC domain of RABGAP1L promotes antiviral activity, and the RABGAP1L proximal interactome uncovered its association with proteins involved in endosomal sorting, maturation, and trafficking. In this regard, RABGAP1L overexpression is sufficient to disrupt endosomal function during IAV infection and restricts an early post-attachment, but pre-fusion, stage of IAV cell entry. Other RNA viruses that enter cells primarily via endocytosis are also impaired by RABGAP1L, while entry promiscuous SARS-CoV-2 is resistant. Our data highlight virus endocytosis as a key target for host defenses. Twit Text FOAVip Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defense ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=35320721 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35320721 #FOAvip English Wikipedia <ref>{{Cite pmid|35320721}}</ref> Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defense #MMPMID35320721 Fernbach S; Spieler EE; Busnadiego I; Karakus U; Lkharrazi A; Stertz S; Hale BG Cell Rep 2022[Mar]; 38 (12): 110549 PMID35320721show ga Host interferons (IFNs) powerfully restrict viruses through the action of several hundred IFN-stimulated gene (ISG) products, many of which remain uncharacterized. Here, using RNAi screening, we identify several ISG restriction factors with previously undescribed contributions to IFN-mediated defense. Notably, RABGAP1L, a Tre2/Bub2/Cdc16 (TBC)-domain-containing protein involved in regulation of small membrane-bound GTPases, robustly potentiates IFN action against influenza A viruses (IAVs). Functional studies reveal that the catalytically active TBC domain of RABGAP1L promotes antiviral activity, and the RABGAP1L proximal interactome uncovered its association with proteins involved in endosomal sorting, maturation, and trafficking. In this regard, RABGAP1L overexpression is sufficient to disrupt endosomal function during IAV infection and restricts an early post-attachment, but pre-fusion, stage of IAV cell entry. Other RNA viruses that enter cells primarily via endocytosis are also impaired by RABGAP1L, while entry promiscuous SARS-CoV-2 is resistant. Our data highlight virus endocytosis as a key target for host defenses. |*Antiviral Agents[MESH] |*COVID-19[MESH] |Cell Line[MESH] |Endocytosis[MESH] |Humans[MESH]Restriction factor screening identifies RABGAP1L-mediated disruption o(epmc).pdf DeepDyve Pubget Overpricing