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10.1084/jem.20211387 http://scihub22266oqcxt.onion/10.1084/jem.20211387 35319722!8952682!35319722     free     free     free       J+Exp+Med 2022 ; 219 (4): ä Nephropedia Template TP {{tp|p=35319722|t=2022. Human autoantibodies underlying infectious diseases |pdf=|usr=}}{{35319722}} gab.com Text Human autoantibodies underlying infectious diseases JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=35319722 #FOAvip The vast interindividual clinical variability observed in any microbial infection-ranging from silent infection to lethal disease-is increasingly being explained by human genetic and immunological determinants. Autoantibodies neutralizing specific cytokines underlie the same infectious diseases as inborn errors of the corresponding cytokine or response pathway. Autoantibodies against type I IFNs underlie COVID-19 pneumonia and adverse reactions to the live attenuated yellow fever virus vaccine. Autoantibodies against type II IFN underlie severe disease caused by environmental or tuberculous mycobacteria, and other intra-macrophagic microbes. Autoantibodies against IL-17A/F and IL-6 are less common and underlie mucocutaneous candidiasis and staphylococcal diseases, respectively. Inborn errors of and autoantibodies against GM-CSF underlie pulmonary alveolar proteinosis; associated infections are less well characterized. In individual patients, autoantibodies against cytokines preexist infection with the pathogen concerned and underlie the infectious disease. Human antibody-driven autoimmunity can interfere with cytokines that are essential for protective immunity to specific infectious agents but that are otherwise redundant, thereby underlying specific infectious diseases. Twit Text FOAVip Human autoantibodies underlying infectious diseases ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=35319722 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35319722 #FOAvip English Wikipedia <ref>{{Cite pmid|35319722}}</ref> Human autoantibodies underlying infectious diseases #MMPMID35319722 Puel A; Bastard P; Bustamante J; Casanova JL J Exp Med 2022[Apr]; 219 (4): ä PMID35319722show ga The vast interindividual clinical variability observed in any microbial infection-ranging from silent infection to lethal disease-is increasingly being explained by human genetic and immunological determinants. Autoantibodies neutralizing specific cytokines underlie the same infectious diseases as inborn errors of the corresponding cytokine or response pathway. Autoantibodies against type I IFNs underlie COVID-19 pneumonia and adverse reactions to the live attenuated yellow fever virus vaccine. Autoantibodies against type II IFN underlie severe disease caused by environmental or tuberculous mycobacteria, and other intra-macrophagic microbes. Autoantibodies against IL-17A/F and IL-6 are less common and underlie mucocutaneous candidiasis and staphylococcal diseases, respectively. Inborn errors of and autoantibodies against GM-CSF underlie pulmonary alveolar proteinosis; associated infections are less well characterized. In individual patients, autoantibodies against cytokines preexist infection with the pathogen concerned and underlie the infectious disease. Human antibody-driven autoimmunity can interfere with cytokines that are essential for protective immunity to specific infectious agents but that are otherwise redundant, thereby underlying specific infectious diseases. |*COVID-19[MESH] |*Candidiasis, Chronic Mucocutaneous/genetics[MESH] |*Communicable Diseases[MESH] |*Pulmonary Alveolar Proteinosis[MESH] |Autoantibodies[MESH]Human autoantibodies underlying infectious diseases (epmc).pdf DeepDyve Pubget Overpricing