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10.1016/j.biomaterials.2022.121474 http://scihub22266oqcxt.onion/10.1016/j.biomaterials.2022.121474 35316662!ä!35316662 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35316662.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biomaterials 2022 ; 283 (ä): 121474 Nephropedia Template TP {{tp|p=35316662|t=2022. Highly effective rheumatoid arthritis therapy by peptide-promoted nanomodification of mesenchymal stem cells |pdf=|usr=}}{{35316662}} gab.com Text Highly effective rheumatoid arthritis therapy by peptide-promoted nanomodification of mesenchymal stem cells JO: Biomaterials http://www.kidney.de/pget.php?&tw=1&pmid=35316662 #FOAvip Traditional medication is not satisfied in rheumatoid arthritis (RA) therapy due to its long-term side effects and failure in cartilage repair. Nanomodification of mesenchymal stem cells (MSCs) holds promise for lifting such hurdles but delivering therapeutic nanomaterials (NPs) into MSCs remains challenging in this new strategy. Here, we show that CuS@MnO(2) NPs functionalized with a short phage-selected MSC-targeting peptide enabled the NPs to be uptaken by MSCs. The resultant NP-modified MSCs, further loaded with metformin, significantly improved stem cell therapy of RA. Specifically, the NP-modified MSCs survived the RA-associated oxidized stress through regulating the stress by the superoxide dismutase (SOD)- and catalase (CAT)-like activity of the NPs. They also exhibited an increased capability of cell migration, anti-inflammation, and chondrogenesis due to the nanomodification, thereby effectively inhibiting synovial inflammation and reducing cartilage erosion to relieve RA symptoms in two rat models 28 days post intravenous injection. Our peptide-promoted NP-modified MSCs may be used to enhance therapeutic effects in treating not only RA but also other degenerative and inflammatory diseases. Twit Text FOAVip Highly effective rheumatoid arthritis therapy by peptide-promoted nanomodification of mesenchymal stem cells ????Biomaterials http://www.kidney.de/pget.php?&tw=1&pmid=35316662 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35316662 #FOAvip English Wikipedia <ref>{{Cite pmid|35316662}}</ref> Highly effective rheumatoid arthritis therapy by peptide-promoted nanomodification of mesenchymal stem cells #MMPMID35316662 Lu Y; Li Z; Li L; Chen J; Xu X; Lin Z; Zhang T; Zhu Y; Ding C; Mao C Biomaterials 2022[Apr]; 283 (ä): 121474 PMID35316662show ga Traditional medication is not satisfied in rheumatoid arthritis (RA) therapy due to its long-term side effects and failure in cartilage repair. Nanomodification of mesenchymal stem cells (MSCs) holds promise for lifting such hurdles but delivering therapeutic nanomaterials (NPs) into MSCs remains challenging in this new strategy. Here, we show that CuS@MnO(2) NPs functionalized with a short phage-selected MSC-targeting peptide enabled the NPs to be uptaken by MSCs. The resultant NP-modified MSCs, further loaded with metformin, significantly improved stem cell therapy of RA. Specifically, the NP-modified MSCs survived the RA-associated oxidized stress through regulating the stress by the superoxide dismutase (SOD)- and catalase (CAT)-like activity of the NPs. They also exhibited an increased capability of cell migration, anti-inflammation, and chondrogenesis due to the nanomodification, thereby effectively inhibiting synovial inflammation and reducing cartilage erosion to relieve RA symptoms in two rat models 28 days post intravenous injection. Our peptide-promoted NP-modified MSCs may be used to enhance therapeutic effects in treating not only RA but also other degenerative and inflammatory diseases. |*Arthritis, Rheumatoid/therapy[MESH] |*Mesenchymal Stem Cells/physiology[MESH] |Animals[MESH] |Manganese Compounds[MESH] |Oxides[MESH] |Peptides[MESH]Highly effective rheumatoid arthritis therapy by peptide-promoted nan(epmc).pdf DeepDyve Pubget Overpricing