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10.3389/fmed.2022.846173

http://scihub22266oqcxt.onion/10.3389/fmed.2022.846173
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suck abstract from ncbi


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pmid35308512      Front+Med+(Lausanne) 2022 ; 9 (ä): 846173
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  • Collapsing Glomerulopathy: A Review by the Collapsing Brazilian Consortium #MMPMID35308512
  • Cutrim EMM; Neves PDMM; Campos MAG; Wanderley DC; Teixeira-Junior AAL; Muniz MPR; Ladchumananandasivam FR; Gomes OV; Vasco RFV; Brito DJA; Lages JS; Salgado-Filho N; Guedes FL; de Almeida JB; Magalhaes M; Araujo SA; Silva GEB
  • Front Med (Lausanne) 2022[]; 9 (ä): 846173 PMID35308512show ga
  • Collapsing glomerulopathy (CG) is a clinicopathologic entity characterized by segmentar or global collapse of the glomerulus and hypertrophy and hyperplasia of podocytes. The Columbia classification of 2004 classified CG as a histological subtype of focal segmental glomerulosclerosis (FSGS). A growing number of studies have demonstrated a high prevalence of CG in many countries, especially among populations with a higher proportion of people with African descent. The present study is a narrative review of articles extracted from PubMed, Medline, and Scielo databases from September 1, 2020 to December 31, 2021. We have focused on populational studies (specially cross-sectional and cohort articles). CG is defined as a podocytopathy with a distinct pathogenesis characterized by strong podocyte proliferative activity. The most significant risk factors for CG include APOL1 gene mutations and infections with human immunodeficiency virus and severe acute respiratory syndrome coronavirus 2. CG typically presents with more severe symptoms and greater renal damage. The prognosis is notably worse than that of other FSGS subtypes.
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