Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1007/s00251-022-01257-6 http://scihub22266oqcxt.onion/10.1007/s00251-022-01257-6 35303126!8931451!35303126     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35303126.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunogenetics 2022 ; 74 (5): 455-463 Nephropedia Template TP {{tp|p=35303126|t=2022. Identification of G-quadruplex DNA sequences in SARS-CoV2 |pdf=|usr=}}{{35303126}} gab.com Text Identification of G-quadruplex DNA sequences in SARS-CoV2 JO: Immunogenetics http://www.kidney.de/pget.php?&tw=1&pmid=35303126 #FOAvip G-quadruplex structure or Putative Quadruplex Sequences (PQSs) are abundant in human, microbial, DNA, or RNA viral genomes. These sequences in RNA viral genome play critical roles in integration into human genome as LTR (Long Terminal Repeat), genome replication, chromatin rearrangements, gene regulation, antigen variation (Av), and virulence. Here, we investigated whether the genome of SARS-CoV2, an RNA virus, contained such potential G-quadruplex structures. Using bioinformatic tools, we searched for such sequences and found thirty-seven (forward strand (twenty-five) + reverse strand (Twelve)) QGRSs (Quadruplex forming G-Rich Sequences)/PQSs in SARS-CoV2 genome. These sequences are dispersed mainly in the upstream of SARS-CoV2 genes. We discuss whether existing PQS/QGRS ligands could inhibit the SARS-CoV2 replication and gene transcription as has been observed in other RNA viruses. Further experimental validation would determine the role of these G-quadruplex sequences in SARS-CoV2 genome function to survive in the host cells and identify therapeutic agents to destabilize these PQSs/QGRSs. Twit Text FOAVip Identification of G-quadruplex DNA sequences in SARS-CoV2 ????Immunogenetics http://www.kidney.de/pget.php?&tw=1&pmid=35303126 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35303126 #FOAvip English Wikipedia <ref>{{Cite pmid|35303126}}</ref> Identification of G-quadruplex DNA sequences in SARS-CoV2 #MMPMID35303126 Maiti AK Immunogenetics 2022[Oct]; 74 (5): 455-463 PMID35303126show ga G-quadruplex structure or Putative Quadruplex Sequences (PQSs) are abundant in human, microbial, DNA, or RNA viral genomes. These sequences in RNA viral genome play critical roles in integration into human genome as LTR (Long Terminal Repeat), genome replication, chromatin rearrangements, gene regulation, antigen variation (Av), and virulence. Here, we investigated whether the genome of SARS-CoV2, an RNA virus, contained such potential G-quadruplex structures. Using bioinformatic tools, we searched for such sequences and found thirty-seven (forward strand (twenty-five) + reverse strand (Twelve)) QGRSs (Quadruplex forming G-Rich Sequences)/PQSs in SARS-CoV2 genome. These sequences are dispersed mainly in the upstream of SARS-CoV2 genes. We discuss whether existing PQS/QGRS ligands could inhibit the SARS-CoV2 replication and gene transcription as has been observed in other RNA viruses. Further experimental validation would determine the role of these G-quadruplex sequences in SARS-CoV2 genome function to survive in the host cells and identify therapeutic agents to destabilize these PQSs/QGRSs. |*COVID-19/genetics[MESH] |*G-Quadruplexes[MESH] |DNA[MESH] |Humans[MESH] |RNA, Viral/chemistry/genetics[MESH]Identification of G-quadruplex DNA sequences in SARS-CoV2 (epmc).pdf DeepDyve Pubget Overpricing