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10.1038/s41590-022-01152-y http://scihub22266oqcxt.onion/10.1038/s41590-022-01152-y 35301508!8989655!35301508     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35301508.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Immunol 2022 ; 23 (4): 632-642 Nephropedia Template TP {{tp|p=35301508|t=2022. Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells |pdf=|usr=}}{{35301508}} gab.com Text Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=35301508 #FOAvip Although inhibition of T cell coinhibitory receptors has revolutionized cancer therapy, the mechanisms governing their expression on human T cells have not been elucidated. In the present study, we show that type 1 interferon (IFN-I) regulates coinhibitory receptor expression on human T cells, inducing PD-1/TIM-3/LAG-3 while inhibiting TIGIT expression. High-temporal-resolution mRNA profiling of IFN-I responses established the dynamic regulatory networks uncovering three temporal transcriptional waves. Perturbation of key transcription factors (TFs) and TF footprint analysis revealed two regulator modules with different temporal kinetics that control expression of coinhibitory receptors and IFN-I response genes, with SP140 highlighted as one of the key regulators that differentiates LAG-3 and TIGIT expression. Finally, we found that the dynamic IFN-I response in vitro closely mirrored T cell features in acute SARS-CoV-2 infection. The identification of unique TFs controlling coinhibitory receptor expression under IFN-I response may provide targets for enhancement of immunotherapy in cancer, infectious diseases and autoimmunity. Twit Text FOAVip Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=35301508 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35301508 #FOAvip English Wikipedia <ref>{{Cite pmid|35301508}}</ref> Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells #MMPMID35301508 Sumida TS; Dulberg S; Schupp JC; Lincoln MR; Stillwell HA; Axisa PP; Comi M; Unterman A; Kaminski N; Madi A; Kuchroo VK; Hafler DA Nat Immunol 2022[Apr]; 23 (4): 632-642 PMID35301508show ga Although inhibition of T cell coinhibitory receptors has revolutionized cancer therapy, the mechanisms governing their expression on human T cells have not been elucidated. In the present study, we show that type 1 interferon (IFN-I) regulates coinhibitory receptor expression on human T cells, inducing PD-1/TIM-3/LAG-3 while inhibiting TIGIT expression. High-temporal-resolution mRNA profiling of IFN-I responses established the dynamic regulatory networks uncovering three temporal transcriptional waves. Perturbation of key transcription factors (TFs) and TF footprint analysis revealed two regulator modules with different temporal kinetics that control expression of coinhibitory receptors and IFN-I response genes, with SP140 highlighted as one of the key regulators that differentiates LAG-3 and TIGIT expression. Finally, we found that the dynamic IFN-I response in vitro closely mirrored T cell features in acute SARS-CoV-2 infection. The identification of unique TFs controlling coinhibitory receptor expression under IFN-I response may provide targets for enhancement of immunotherapy in cancer, infectious diseases and autoimmunity. |*COVID-19[MESH] |*Interferon Type I/genetics[MESH] |Gene Regulatory Networks[MESH] |Humans[MESH] |Receptors, Antigen, T-Cell/metabolism[MESH] |Receptors, Immunologic/genetics[MESH] |SARS-CoV-2[MESH]Type I interferon transcriptional network regulates expression of coin(epmc).pdf DeepDyve Pubget Overpricing