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10.1038/s41467-022-29135-5

http://scihub22266oqcxt.onion/10.1038/s41467-022-29135-5
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35301316!8931161!35301316
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suck abstract from ncbi


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pmid35301316      Nat+Commun 2022 ; 13 (1): 1444
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  • RNA G-quadruplex in TMPRSS2 reduces SARS-CoV-2 infection #MMPMID35301316
  • Liu G; Du W; Sang X; Tong Q; Wang Y; Chen G; Yuan Y; Jiang L; Cheng W; Liu D; Tian Y; Fu X
  • Nat Commun 2022[Mar]; 13 (1): 1444 PMID35301316show ga
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection continues to have devastating consequences worldwide. Recently, great efforts have been made to identify SARS-CoV-2 host factors, but the regulatory mechanisms of these host molecules, as well as the virus per se, remain elusive. Here we report a role of RNA G-quadruplex (RG4) in SARS-CoV-2 infection. Combining bioinformatics, biochemical and biophysical assays, we demonstrate the presence of RG4s in both SARS-CoV-2 genome and host factors. The biological and pathological importance of these RG4s is then exemplified by a canonical 3-quartet RG4 within Tmprss2, which can inhibit Tmprss2 translation and prevent SARS-CoV-2 entry. Intriguingly, G-quadruplex (G4)-specific stabilizers attenuate SARS-CoV-2 infection in pseudovirus cell systems and mouse models. Consistently, the protein level of TMPRSS2 is increased in lungs of COVID-19 patients. Our findings reveal a previously unknown mechanism underlying SARS-CoV-2 infection and suggest RG4 as a potential target for COVID-19 prevention and treatment.
  • |*COVID-19[MESH]
  • |*Virus Internalization[MESH]
  • |Animals[MESH]
  • |Humans[MESH]
  • |Mice[MESH]
  • |RNA[MESH]
  • |SARS-CoV-2[MESH]


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