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10.1016/j.ijbiomac.2022.03.058

http://scihub22266oqcxt.onion/10.1016/j.ijbiomac.2022.03.058
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suck abstract from ncbi


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pmid35300999      Int+J+Biol+Macromol 2022 ; 208 (ä): 105-125
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  • The spike glycoprotein of SARS-CoV-2: A review of how mutations of spike glycoproteins have driven the emergence of variants with high transmissibility and immune escape #MMPMID35300999
  • Souza PFN; Mesquita FP; Amaral JL; Landim PGC; Lima KRP; Costa MB; Farias IR; Belem MO; Pinto YO; Moreira HHT; Magalhaes ICL; Castelo-Branco DSCM; Montenegro RC; de Andrade CR
  • Int J Biol Macromol 2022[May]; 208 (ä): 105-125 PMID35300999show ga
  • Late in 2019, SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) emerged, causing an unknown type of pneumonia today called coronaviruses disease 2019 (COVID-19). COVID-19 is still an ongoing global outbreak that has claimed and threatened many lives worldwide. Along with the fastest vaccine developed in history to fight SARS-CoV-2 came a critical problem, SARS-CoV-2. These new variants are a result of the accumulation of mutations in the sequence and structure of spike (S) glycoprotein, which is by far the most critical protein for SARS-CoV-2 to recognize cells and escape the immune system, in addition to playing a role in SARS-CoV-2 infection, pathogenicity, transmission, and evolution. In this review, we discuss mutation of S protein and how these mutations have led to new variants that are usually more transmissible and can thus mitigate the immunity produced by vaccination. Here, analysis of S protein sequences and structures from variants point out the mutations among them, how they emerge, and the behavior of S protein from each variant. This review brings details in an understandable way about how the variants of SARS-CoV-2 are a result of mutations in S protein, making them more transmissible and even more aggressive than their relatives.
  • |*COVID-19/epidemiology[MESH]
  • |*SARS-CoV-2/genetics[MESH]
  • |Glycoproteins/genetics[MESH]
  • |Humans[MESH]
  • |Mutation[MESH]


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