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10.7554/eLife.77444 http://scihub22266oqcxt.onion/10.7554/eLife.77444 35294338!8942469!35294338     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Elife 2022 ; 11 (ä): ä Nephropedia Template TP {{tp|p=35294338|t=2022. Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry |pdf=|usr=}}{{35294338}} gab.com Text Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=35294338 #FOAvip Coagulopathy is a significant aspect of morbidity in COVID-19 patients. The clotting cascade is propagated by a series of proteases, including factor Xa and thrombin. While certain host proteases, including TMPRSS2 and furin, are known to be important for cleavage activation of SARS-CoV-2 spike to promote viral entry in the respiratory tract, other proteases may also contribute. Using biochemical and cell-based assays, we demonstrate that factor Xa and thrombin can also directly cleave SARS-CoV-2 spike, enhancing infection at the stage of viral entry. Coagulation factors increased SARS-CoV-2 infection in human lung organoids. A drug-repurposing screen identified a subset of protease inhibitors that promiscuously inhibited spike cleavage by both transmembrane serine proteases and coagulation factors. The mechanism of the protease inhibitors nafamostat and camostat may extend beyond inhibition of TMPRSS2 to coagulation-induced spike cleavage. Anticoagulation is critical in the management of COVID-19, and early intervention could provide collateral benefit by suppressing SARS-CoV-2 viral entry. We propose a model of positive feedback whereby infection-induced hypercoagulation exacerbates SARS-CoV-2 infectivity. Twit Text FOAVip Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=35294338 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35294338 #FOAvip English Wikipedia <ref>{{Cite pmid|35294338}}</ref> Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry #MMPMID35294338 Kastenhuber ER; Mercadante M; Nilsson-Payant B; Johnson JL; Jaimes JA; Muecksch F; Weisblum Y; Bram Y; Chandar V; Whittaker GR; tenOever BR; Schwartz RE; Cantley L Elife 2022[Mar]; 11 (ä): ä PMID35294338show ga Coagulopathy is a significant aspect of morbidity in COVID-19 patients. The clotting cascade is propagated by a series of proteases, including factor Xa and thrombin. While certain host proteases, including TMPRSS2 and furin, are known to be important for cleavage activation of SARS-CoV-2 spike to promote viral entry in the respiratory tract, other proteases may also contribute. Using biochemical and cell-based assays, we demonstrate that factor Xa and thrombin can also directly cleave SARS-CoV-2 spike, enhancing infection at the stage of viral entry. Coagulation factors increased SARS-CoV-2 infection in human lung organoids. A drug-repurposing screen identified a subset of protease inhibitors that promiscuously inhibited spike cleavage by both transmembrane serine proteases and coagulation factors. The mechanism of the protease inhibitors nafamostat and camostat may extend beyond inhibition of TMPRSS2 to coagulation-induced spike cleavage. Anticoagulation is critical in the management of COVID-19, and early intervention could provide collateral benefit by suppressing SARS-CoV-2 viral entry. We propose a model of positive feedback whereby infection-induced hypercoagulation exacerbates SARS-CoV-2 infectivity. |*COVID-19[MESH] |*SARS-CoV-2[MESH] |Blood Coagulation Factors[MESH] |Humans[MESH] |Spike Glycoprotein, Coronavirus[MESH]Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral(epmc).pdf DeepDyve Pubget Overpricing