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10.15698/mic2022.03.772 http://scihub22266oqcxt.onion/10.15698/mic2022.03.772 35291313!8890622!35291313     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Microb+Cell 2022 ; 9 (3): 69-71 Nephropedia Template TP {{tp|p=35291313|t=2022. An ionophore breaks the multi-drug-resistance of Acinetobacter baumannii |pdf=|usr=}}{{35291313}} gab.com Text An ionophore breaks the multi-drug-resistance of Acinetobacter baumannii JO: Microb Cell http://www.kidney.de/pget.php?&tw=1&pmid=35291313 #FOAvip Within intensive care units, multi-drug resistant Acinetobacter baumannii outbreaks are a frequent cause of ventilator-associated pneumonia. During the on-going COVID-19 pandemic, patients who receive ventilator support experience a 2-fold increased risk of mortality when they contract a secondary A. baumannii pulmonary infection. In our recent paper (De Oliveira et al. (2022), Mbio, doi: 10.1128/mbio.03517-21), we demonstrate that the 8-hydroxquinoline ionophore, PBT2 breaks the resistance of A. baumannii to tetracycline class antibiotics. In vitro, the combination of PBT2 and zinc with either tetracycline, doxycycline, or tigecycline was shown to be bactericidal against multi-drug-resistant A. baumannii, and any resistance that did arise imposed a fitness cost. Using a murine model of pulmonary infection, treatment with PBT2 in combination with tetracycline or tigecycline proved efficacious against multidrug-resistant A. baumannii. These findings suggest that PBT2 may find utility as a resistance breaker to rescue the efficacy of tetracycline-class antibiotics commonly employed to treat multi-drug resistant A. baumannii infections. Twit Text FOAVip An ionophore breaks the multi-drug-resistance of Acinetobacter baumannii ????Microb Cell http://www.kidney.de/pget.php?&tw=1&pmid=35291313 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35291313 #FOAvip English Wikipedia <ref>{{Cite pmid|35291313}}</ref> An ionophore breaks the multi-drug-resistance of Acinetobacter baumannii #MMPMID35291313 De Oliveira DMP; Walker MJ Microb Cell 2022[Mar]; 9 (3): 69-71 PMID35291313show ga Within intensive care units, multi-drug resistant Acinetobacter baumannii outbreaks are a frequent cause of ventilator-associated pneumonia. During the on-going COVID-19 pandemic, patients who receive ventilator support experience a 2-fold increased risk of mortality when they contract a secondary A. baumannii pulmonary infection. In our recent paper (De Oliveira et al. (2022), Mbio, doi: 10.1128/mbio.03517-21), we demonstrate that the 8-hydroxquinoline ionophore, PBT2 breaks the resistance of A. baumannii to tetracycline class antibiotics. In vitro, the combination of PBT2 and zinc with either tetracycline, doxycycline, or tigecycline was shown to be bactericidal against multi-drug-resistant A. baumannii, and any resistance that did arise imposed a fitness cost. Using a murine model of pulmonary infection, treatment with PBT2 in combination with tetracycline or tigecycline proved efficacious against multidrug-resistant A. baumannii. These findings suggest that PBT2 may find utility as a resistance breaker to rescue the efficacy of tetracycline-class antibiotics commonly employed to treat multi-drug resistant A. baumannii infections. äAn ionophore breaks the multi-drug-resistance of Acinetobacter baumann(epmc).pdf DeepDyve Pubget Overpricing