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10.1007/s11427-021-2070-y http://scihub22266oqcxt.onion/10.1007/s11427-021-2070-y 35290573!8922985!35290573     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+China+Life+Sci 2022 ; 65 (9): 1866-1880 Nephropedia Template TP {{tp|p=35290573|t=2022. A urinary proteomic landscape of COVID-19 progression identifies signaling pathways and therapeutic options |pdf=|usr=}}{{35290573}} gab.com Text A urinary proteomic landscape of COVID-19 progression identifies signaling pathways and therapeutic options JO: Sci China Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=35290573 #FOAvip Signaling pathway alterations in COVID-19 of living humans as well as therapeutic targets of the host proteins are not clear. We analyzed 317 urine proteomes, including 86 COVID-19, 55 pneumonia and 176 healthy controls, and identified specific RNA virus detector protein DDX58/RIG-I only in COVID-19 samples. Comparison of the COVID-19 urinary proteomes with controls revealed major pathway alterations in immunity, metabolism and protein localization. Biomarkers that may stratify severe symptoms from moderate ones suggested that macrophage induced inflammation and thrombolysis may play a critical role in worsening the disease. Hyper activation of the TCA cycle is evident and a macrophage enriched enzyme CLYBL is up regulated in COVID-19 patients. As CLYBL converts the immune modulatory TCA cycle metabolite itaconate through the citramalyl-CoA intermediate to acetyl-CoA, an increase in CLYBL may lead to the depletion of itaconate, limiting its anti-inflammatory function. These observations suggest that supplementation of itaconate and inhibition of CLYBL are possible therapeutic options for treating COVID-19, opening an avenue of modulating host defense as a means of combating SARS-CoV-2 viruses. Twit Text FOAVip A urinary proteomic landscape of COVID-19 progression identifies signaling pathways and therapeutic options ????Sci China Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=35290573 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35290573 #FOAvip English Wikipedia <ref>{{Cite pmid|35290573}}</ref> A urinary proteomic landscape of COVID-19 progression identifies signaling pathways and therapeutic options #MMPMID35290573 Liu Y; Song L; Zheng N; Shi J; Wu H; Yang X; Xue N; Chen X; Li Y; Sun C; Chen C; Tang L; Ni X; Wang Y; Shi Y; Guo J; Wang G; Zhang Z; Qin J Sci China Life Sci 2022[Sep]; 65 (9): 1866-1880 PMID35290573show ga Signaling pathway alterations in COVID-19 of living humans as well as therapeutic targets of the host proteins are not clear. We analyzed 317 urine proteomes, including 86 COVID-19, 55 pneumonia and 176 healthy controls, and identified specific RNA virus detector protein DDX58/RIG-I only in COVID-19 samples. Comparison of the COVID-19 urinary proteomes with controls revealed major pathway alterations in immunity, metabolism and protein localization. Biomarkers that may stratify severe symptoms from moderate ones suggested that macrophage induced inflammation and thrombolysis may play a critical role in worsening the disease. Hyper activation of the TCA cycle is evident and a macrophage enriched enzyme CLYBL is up regulated in COVID-19 patients. As CLYBL converts the immune modulatory TCA cycle metabolite itaconate through the citramalyl-CoA intermediate to acetyl-CoA, an increase in CLYBL may lead to the depletion of itaconate, limiting its anti-inflammatory function. These observations suggest that supplementation of itaconate and inhibition of CLYBL are possible therapeutic options for treating COVID-19, opening an avenue of modulating host defense as a means of combating SARS-CoV-2 viruses. |*COVID-19[MESH] |Humans[MESH] |Proteome[MESH] |Proteomics[MESH] |SARS-CoV-2[MESH]A urinary proteomic landscape of COVID-19 progression identifies signa(epmc).pdf DeepDyve Pubget Overpricing