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10.3390/cells11050847 http://scihub22266oqcxt.onion/10.3390/cells11050847 35269470!8909161!35269470     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\35269470.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cells 2022 ; 11 (5): ä Nephropedia Template TP {{tp|p=35269470|t=2022. Severe COVID-19 Shares a Common Neutrophil Activation Signature with Other Acute Inflammatory States |pdf=|usr=}}{{35269470}} gab.com Text Severe COVID-19 Shares a Common Neutrophil Activation Signature with Other Acute Inflammatory States JO: Cells http://www.kidney.de/pget.php?&tw=1&pmid=35269470 #FOAvip Severe COVID-19 patients present a clinical and laboratory overlap with other hyperinflammatory conditions such as hemophagocytic lymphohistiocytosis (HLH). However, the underlying mechanisms of these conditions remain to be explored. Here, we investigated the transcriptome of 1596 individuals, including patients with COVID-19 in comparison to healthy controls, other acute inflammatory states (HLH, multisystem inflammatory syndrome in children [MIS-C], Kawasaki disease [KD]), and different respiratory infections (seasonal coronavirus, influenza, bacterial pneumonia). We observed that COVID-19 and HLH share immunological pathways (cytokine/chemokine signaling and neutrophil-mediated immune responses), including gene signatures that stratify COVID-19 patients admitted to the intensive care unit (ICU) and COVID-19_nonICU patients. Of note, among the common differentially expressed genes (DEG), there is a cluster of neutrophil-associated genes that reflects a generalized hyperinflammatory state since it is also dysregulated in patients with KD and bacterial pneumonia. These genes are dysregulated at the protein level across several COVID-19 studies and form an interconnected network with differentially expressed plasma proteins that point to neutrophil hyperactivation in COVID-19 patients admitted to the intensive care unit. scRNAseq analysis indicated that these genes are specifically upregulated across different leukocyte populations, including lymphocyte subsets and immature neutrophils. Artificial intelligence modeling confirmed the strong association of these genes with COVID-19 severity. Thus, our work indicates putative therapeutic pathways for intervention. Twit Text FOAVip Severe COVID-19 Shares a Common Neutrophil Activation Signature with Other Acute Inflammatory States ????Cells http://www.kidney.de/pget.php?&tw=1&pmid=35269470 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35269470 #FOAvip English Wikipedia <ref>{{Cite pmid|35269470}}</ref> Severe COVID-19 Shares a Common Neutrophil Activation Signature with Other Acute Inflammatory States #MMPMID35269470 Schimke LF; Marques AHC; Baiocchi GC; de Souza Prado CA; Fonseca DLM; Freire PP; Rodrigues Placa D; Salerno Filgueiras I; Coelho Salgado R; Jansen-Marques G; Rocha Oliveira AE; Peron JPS; Cabral-Miranda G; Barbuto JAM; Camara NOS; Calich VLG; Ochs HD; Condino-Neto A; Overmyer KA; Coon JJ; Balnis J; Jaitovich A; Schulte-Schrepping J; Ulas T; Schultze JL; Nakaya HI; Jurisica I; Cabral-Marques O Cells 2022[Mar]; 11 (5): ä PMID35269470show ga Severe COVID-19 patients present a clinical and laboratory overlap with other hyperinflammatory conditions such as hemophagocytic lymphohistiocytosis (HLH). However, the underlying mechanisms of these conditions remain to be explored. Here, we investigated the transcriptome of 1596 individuals, including patients with COVID-19 in comparison to healthy controls, other acute inflammatory states (HLH, multisystem inflammatory syndrome in children [MIS-C], Kawasaki disease [KD]), and different respiratory infections (seasonal coronavirus, influenza, bacterial pneumonia). We observed that COVID-19 and HLH share immunological pathways (cytokine/chemokine signaling and neutrophil-mediated immune responses), including gene signatures that stratify COVID-19 patients admitted to the intensive care unit (ICU) and COVID-19_nonICU patients. Of note, among the common differentially expressed genes (DEG), there is a cluster of neutrophil-associated genes that reflects a generalized hyperinflammatory state since it is also dysregulated in patients with KD and bacterial pneumonia. These genes are dysregulated at the protein level across several COVID-19 studies and form an interconnected network with differentially expressed plasma proteins that point to neutrophil hyperactivation in COVID-19 patients admitted to the intensive care unit. scRNAseq analysis indicated that these genes are specifically upregulated across different leukocyte populations, including lymphocyte subsets and immature neutrophils. Artificial intelligence modeling confirmed the strong association of these genes with COVID-19 severity. Thus, our work indicates putative therapeutic pathways for intervention. |*COVID-19/complications/genetics[MESH] |*Lymphohistiocytosis, Hemophagocytic/complications[MESH] |Artificial Intelligence[MESH] |Child[MESH] |Humans[MESH] |Neutrophil Activation[MESH] |SARS-CoV-2[MESH]Severe COVID-19 Shares a Common Neutrophil Activation Signature with O(epmc).pdf DeepDyve Pubget Overpricing