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10.1007/s11606-022-07465-w

http://scihub22266oqcxt.onion/10.1007/s11606-022-07465-w
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35266128!8906626!35266128
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suck abstract from ncbi


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pmid35266128      J+Gen+Intern+Med 2022 ; 37 (7): 1748-1753
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  • Association of Vaccination with the Persistence of Post-COVID Symptoms #MMPMID35266128
  • Wisnivesky JP; Govindarajulu U; Bagiella E; Goswami R; Kale M; Campbell KN; Meliambro K; Chen Z; Aberg JA; Lin JJ
  • J Gen Intern Med 2022[May]; 37 (7): 1748-1753 PMID35266128show ga
  • BACKGROUND: Patients who have had COVID-19 often report persistent symptoms after resolution of their acute illness. Recent reports suggest that vaccination may be associated with improvement in post-acute symptoms. We used data from a prospective cohort to assess differences in post-acute sequelae of COVID (PASC) among vaccinated vs. unvaccinated patients. METHODS: We used data from a cohort of COVID-19 patients enrolled into a prospective registry established at a tertiary care health system in New York City. Participants underwent a baseline evaluation before COVID-19 vaccines were available and were followed 6 months later. We compared unadjusted and propensity score-adjusted baseline to 6-month change for several PASC-related symptoms and measures: anosmia, respiratory (cough, dyspnea, phlegm, wheezing), depression, anxiety, post-traumatic stress disorder (PTSD; COVID-19-related and other trauma), and quality-of-life domains among participants who received vs. those who did not receive COVID-19 vaccination. RESULTS: The study included 453 COVID-19 patients with PASC, of which 324 (72%) were vaccinated between the baseline and 6-month visit. Unadjusted analyses did not show significant differences in the baseline to 6-month change in anosmia, respiratory symptoms, depression, anxiety, PTSD, or quality of life (p > 0.05 for all comparisons) among vaccinated vs. unvaccinated patients. Similar results were found in propensity-adjusted comparisons and in secondary analyses based on the number of vaccine doses received. CONCLUSIONS: Our findings suggest that COVID vaccination is not associated with improvement in PASC. Additional studies are needed to better understand the mechanisms underlying PASC and to develop effective treatments.
  • |*COVID-19/epidemiology/prevention & control[MESH]
  • |*SARS-CoV-2[MESH]
  • |Anosmia[MESH]
  • |COVID-19 Vaccines[MESH]
  • |Disease Progression[MESH]
  • |Humans[MESH]
  • |Quality of Life[MESH]


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