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10.1055/a-1788-5206 http://scihub22266oqcxt.onion/10.1055/a-1788-5206 35253140!9393084!35253140     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Thromb+Haemost 2022 ; 122 (8): 1352-1360 Nephropedia Template TP {{tp|p=35253140|t=2022. Assessing Clinically Meaningful Hypercoagulability after COVID-19 Vaccination: A Longitudinal Study |pdf=|usr=}}{{35253140}} gab.com Text Assessing Clinically Meaningful Hypercoagulability after COVID-19 Vaccination: A Longitudinal Study JO: Thromb Haemost http://www.kidney.de/pget.php?&tw=1&pmid=35253140 #FOAvip A large number of daily requests to exclude possible prothrombotic risk factors for coronavirus disease 2019 (COVID-19) vaccines were received. Our aim was to longitudinally evaluate coagulation profiles in a series of healthy subjects who received COVID-19 vaccination and assess hypercoagulability thereafter. Volunteers awaiting a first or second dose of either the ChAdOx1 or BNT162b2 vaccine were enrolled. Venous samples were obtained at baseline (before the vaccine) and longitudinally 3 +/- 2 days (T1) and 10 +/- 2 days after the vaccine (T2). Global coagulation monitoring was assessed via platelet count, whole blood thromboelastometry and impedance aggregometry, plasma thrombin generation, and anti-platelet factor 4 (PF4)/heparin immunoglobulin G antibodies. One hundred and twenty-two subjects were enrolled (61 [50%] ChAdOx1 and 61 BNT162b2). The ChAdOx1 cohort showed a slight but transient increase in thrombin generation (mainly endogenous thrombin potential [ETP] with thrombomodulin and ETP ratio) at T1, which promptly decreased at T2. In addition, the second dose of either vaccine was associated with increased thrombin peak, ETP with thrombomodulin, and ETP ratio. At baseline, 3.2% of the ChAdOx1 cohort and 1.6% BNT162b2 cohort were positive for PF4/heparin antibodies with a stable titer through T1 and T2. No relevant differences were detected in platelet count and aggregation, or thromboelastometry parameters. No thrombotic or hemorrhagic events occurred. We can confirm that no clinically meaningful hypercoagulability occurred after either vaccine, albeit keeping in mind that thrombin generation may increase in the first days after the second dose of either vaccine and after the first dose of the ChAdOx1 vaccine. Twit Text FOAVip Assessing Clinically Meaningful Hypercoagulability after COVID-19 Vaccination: A Longitudinal Study ????Thromb Haemost http://www.kidney.de/pget.php?&tw=1&pmid=35253140 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35253140 #FOAvip English Wikipedia <ref>{{Cite pmid|35253140}}</ref> Assessing Clinically Meaningful Hypercoagulability after COVID-19 Vaccination: A Longitudinal Study #MMPMID35253140 Campello E; Bulato C; Simion C; Spiezia L; Radu CM; Gavasso S; Sartorello F; Saggiorato G; Zerbinati P; Fadin M; Tormene D; Simioni P Thromb Haemost 2022[Aug]; 122 (8): 1352-1360 PMID35253140show ga A large number of daily requests to exclude possible prothrombotic risk factors for coronavirus disease 2019 (COVID-19) vaccines were received. Our aim was to longitudinally evaluate coagulation profiles in a series of healthy subjects who received COVID-19 vaccination and assess hypercoagulability thereafter. Volunteers awaiting a first or second dose of either the ChAdOx1 or BNT162b2 vaccine were enrolled. Venous samples were obtained at baseline (before the vaccine) and longitudinally 3 +/- 2 days (T1) and 10 +/- 2 days after the vaccine (T2). Global coagulation monitoring was assessed via platelet count, whole blood thromboelastometry and impedance aggregometry, plasma thrombin generation, and anti-platelet factor 4 (PF4)/heparin immunoglobulin G antibodies. One hundred and twenty-two subjects were enrolled (61 [50%] ChAdOx1 and 61 BNT162b2). The ChAdOx1 cohort showed a slight but transient increase in thrombin generation (mainly endogenous thrombin potential [ETP] with thrombomodulin and ETP ratio) at T1, which promptly decreased at T2. In addition, the second dose of either vaccine was associated with increased thrombin peak, ETP with thrombomodulin, and ETP ratio. At baseline, 3.2% of the ChAdOx1 cohort and 1.6% BNT162b2 cohort were positive for PF4/heparin antibodies with a stable titer through T1 and T2. No relevant differences were detected in platelet count and aggregation, or thromboelastometry parameters. No thrombotic or hemorrhagic events occurred. We can confirm that no clinically meaningful hypercoagulability occurred after either vaccine, albeit keeping in mind that thrombin generation may increase in the first days after the second dose of either vaccine and after the first dose of the ChAdOx1 vaccine. |*COVID-19 Vaccines/adverse effects[MESH] |*COVID-19/prevention & control[MESH] |*Thrombophilia/diagnosis/etiology[MESH] |BNT162 Vaccine[MESH] |Heparin/adverse effects[MESH] |Humans[MESH] |Longitudinal Studies[MESH] |Thrombin[MESH] |Thrombomodulin[MESH]Assessing Clinically Meaningful Hypercoagulability after COVID-19 Vacc(epmc).pdf DeepDyve Pubget Overpricing