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10.1371/journal.pgen.1010042 http://scihub22266oqcxt.onion/10.1371/journal.pgen.1010042 35239653!8893330!35239653     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=35239653&cmd=llinks): Failed to open stream: HTTP request failed! 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Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19 |pdf=|usr=}}{{35239653}} gab.com Text Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19 JO: PLoS Genet http://www.kidney.de/pget.php?&tw=1&pmid=35239653 #FOAvip In November 2021, the COVID-19 pandemic death toll surpassed five million individuals. We applied Mendelian randomization including >3,000 blood proteins as exposures to identify potential biomarkers that may indicate risk for hospitalization or need for respiratory support or death due to COVID-19, respectively. After multiple testing correction, using genetic instruments and under the assumptions of Mendelian Randomization, our results were consistent with higher blood levels of five proteins GCNT4, CD207, RAB14, C1GALT1C1, and ABO being causally associated with an increased risk of hospitalization or respiratory support/death due to COVID-19 (ORs = 1.12-1.35). Higher levels of FAAH2 were solely associated with an increased risk of hospitalization (OR = 1.19). On the contrary, higher levels of SELL, SELE, and PECAM-1 decrease risk of hospitalization or need for respiratory support/death (ORs = 0.80-0.91). Higher levels of LCTL, SFTPD, KEL, and ATP2A3 were solely associated with a decreased risk of hospitalization (ORs = 0.86-0.93), whilst higher levels of ICAM-1 were solely associated with a decreased risk of respiratory support/death of COVID-19 (OR = 0.84). Our findings implicate blood group markers and binding proteins in both hospitalization and need for respiratory support/death. They, additionally, suggest that higher levels of endocannabinoid enzymes may increase the risk of hospitalization. Our research replicates findings of blood markers previously associated with COVID-19 and prioritises additional blood markers for risk prediction of severe forms of COVID-19. Furthermore, we pinpoint druggable targets potentially implicated in disease pathology. Twit Text FOAVip Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19 ????PLoS Genet http://www.kidney.de/pget.php?&tw=1&pmid=35239653 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35239653 #FOAvip English Wikipedia <ref>{{Cite pmid|35239653}}</ref> Proteome-wide Mendelian randomization identifies causal links between blood proteins and severe COVID-19 #MMPMID35239653 Palmos AB; Millischer V; Menon DK; Nicholson TR; Taams LS; Michael B; Sunderland G; Griffiths MJ; Hubel C; Breen G PLoS Genet 2022[Mar]; 18 (3): e1010042 PMID35239653show ga In November 2021, the COVID-19 pandemic death toll surpassed five million individuals. We applied Mendelian randomization including >3,000 blood proteins as exposures to identify potential biomarkers that may indicate risk for hospitalization or need for respiratory support or death due to COVID-19, respectively. After multiple testing correction, using genetic instruments and under the assumptions of Mendelian Randomization, our results were consistent with higher blood levels of five proteins GCNT4, CD207, RAB14, C1GALT1C1, and ABO being causally associated with an increased risk of hospitalization or respiratory support/death due to COVID-19 (ORs = 1.12-1.35). Higher levels of FAAH2 were solely associated with an increased risk of hospitalization (OR = 1.19). On the contrary, higher levels of SELL, SELE, and PECAM-1 decrease risk of hospitalization or need for respiratory support/death (ORs = 0.80-0.91). Higher levels of LCTL, SFTPD, KEL, and ATP2A3 were solely associated with a decreased risk of hospitalization (ORs = 0.86-0.93), whilst higher levels of ICAM-1 were solely associated with a decreased risk of respiratory support/death of COVID-19 (OR = 0.84). Our findings implicate blood group markers and binding proteins in both hospitalization and need for respiratory support/death. They, additionally, suggest that higher levels of endocannabinoid enzymes may increase the risk of hospitalization. Our research replicates findings of blood markers previously associated with COVID-19 and prioritises additional blood markers for risk prediction of severe forms of COVID-19. Furthermore, we pinpoint druggable targets potentially implicated in disease pathology. |Biomarkers/analysis/blood[MESH] |Blood Proteins/analysis/genetics/*metabolism[MESH] |COVID-19/*blood/diagnosis/mortality/*pathology[MESH] |Causality[MESH] |Genome-Wide Association Study[MESH] |Hospitalization[MESH] |Humans[MESH] |Mendelian Randomization Analysis[MESH] |Mortality[MESH] |Pandemics[MESH] |Polymorphism, Single Nucleotide[MESH] |Prognosis[MESH] |Proteome/analysis/genetics/metabolism[MESH] |Respiratory Insufficiency/blood/diagnosis/mortality/pathology[MESH] |Risk Factors[MESH] |SARS-CoV-2/physiology[MESH]Proteome-wide Mendelian randomization identifies causal links between (epmc).pdf DeepDyve Pubget Overpricing