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10.1038/s41594-022-00735-5 http://scihub22266oqcxt.onion/10.1038/s41594-022-00735-5 35236990!9007726!35236990     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Struct+Mol+Biol 2022 ; 29 (3): 229-238 Nephropedia Template TP {{tp|p=35236990|t=2022. The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopes |pdf=|usr=}}{{35236990}} gab.com Text The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopes JO: Nat Struct Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=35236990 #FOAvip Current COVID-19 vaccines and many clinical diagnostics are based on the structure and function of the SARS-CoV-2 spike ectodomain. Using hydrogen-deuterium exchange monitored by mass spectrometry, we have uncovered that, in addition to the prefusion structure determined by cryo-electron microscopy, this protein adopts an alternative conformation that interconverts slowly with the canonical prefusion structure. This new conformation-an open trimer-contains easily accessible receptor-binding domains. It exposes the conserved trimer interface buried in the prefusion conformation, thus exposing potential epitopes for pan-coronavirus antibody and ligand recognition. The population of this state and kinetics of interconversion are modulated by temperature, receptor binding, antibody binding, and sequence variants observed in the natural population. Knowledge of the structure and populations of this conformation will help improve existing diagnostics, therapeutics, and vaccines. Twit Text FOAVip The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopes ????Nat Struct Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=35236990 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35236990 #FOAvip English Wikipedia <ref>{{Cite pmid|35236990}}</ref> The SARS-CoV-2 spike reversibly samples an open-trimer conformation exposing novel epitopes #MMPMID35236990 Costello SM; Shoemaker SR; Hobbs HT; Nguyen AW; Hsieh CL; Maynard JA; McLellan JS; Pak JE; Marqusee S Nat Struct Mol Biol 2022[Mar]; 29 (3): 229-238 PMID35236990show ga Current COVID-19 vaccines and many clinical diagnostics are based on the structure and function of the SARS-CoV-2 spike ectodomain. Using hydrogen-deuterium exchange monitored by mass spectrometry, we have uncovered that, in addition to the prefusion structure determined by cryo-electron microscopy, this protein adopts an alternative conformation that interconverts slowly with the canonical prefusion structure. This new conformation-an open trimer-contains easily accessible receptor-binding domains. It exposes the conserved trimer interface buried in the prefusion conformation, thus exposing potential epitopes for pan-coronavirus antibody and ligand recognition. The population of this state and kinetics of interconversion are modulated by temperature, receptor binding, antibody binding, and sequence variants observed in the natural population. Knowledge of the structure and populations of this conformation will help improve existing diagnostics, therapeutics, and vaccines. |*COVID-19[MESH] |*Spike Glycoprotein, Coronavirus/chemistry[MESH] |Antibodies, Neutralizing[MESH] |COVID-19 Vaccines[MESH] |Cryoelectron Microscopy[MESH] |Epitopes[MESH] |Humans[MESH] |Protein Conformation[MESH]The SARS-CoV-2 spike reversibly samples an open-trimer conformation ex(epmc).pdf DeepDyve Pubget Overpricing