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10.1016/j.celrep.2022.110502

http://scihub22266oqcxt.onion/10.1016/j.celrep.2022.110502
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35235831!8858710!35235831
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suck abstract from ncbi


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pmid35235831      Cell+Rep 2022 ; 38 (10): 110502
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  • BCG vaccination provides protection against IAV but not SARS-CoV-2 #MMPMID35235831
  • Kaufmann E; Khan N; Tran KA; Ulndreaj A; Pernet E; Fontes G; Lupien A; Desmeules P; McIntosh F; Abow A; Moorlag SJCFM; Debisarun P; Mossman K; Banerjee A; Karo-Atar D; Sadeghi M; Mubareka S; Vinh DC; King IL; Robbins CS; Behr MA; Netea MG; Joubert P; Divangahi M
  • Cell Rep 2022[Mar]; 38 (10): 110502 PMID35235831show ga
  • Since the vast majority of species solely rely on innate immunity for host defense, it stands to reason that a critical evolutionary trait like immunological memory evolved in this primitive branch of our immune system. There is ample evidence that vaccines such as bacillus Calmette-Guerin (BCG) induce protective innate immune memory responses (trained immunity) against heterologous pathogens. Here we show that while BCG vaccination significantly reduces morbidity and mortality against influenza A virus (IAV), it fails to provide protection against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In contrast to IAV, SARS-CoV-2 infection leads to unique pulmonary vasculature damage facilitating viral dissemination to other organs, including the bone marrow (BM), a central site for BCG-mediated trained immunity. Finally, monocytes from BCG-vaccinated individuals mount an efficient cytokine response to IAV infection, while this response is minimal following SARS-CoV-2. Collectively, our data suggest that the protective capacity of BCG vaccination is contingent on viral pathogenesis and tissue tropism.
  • |*COVID-19/prevention & control[MESH]
  • |*Influenza A virus[MESH]
  • |BCG Vaccine[MESH]
  • |Humans[MESH]
  • |Immunity, Innate[MESH]
  • |SARS-CoV-2[MESH]


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