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10.1007/s43657-021-00015-0 http://scihub22266oqcxt.onion/10.1007/s43657-021-00015-0 35233559!8277987!35233559     free     free     free       Phenomics 2021 ; 1 (3): 113-128 Nephropedia Template TP {{tp|p=35233559|t=2021. Defense of COVID-19 by Human Organoids |pdf=|usr=}}{{35233559}} gab.com Text Defense of COVID-19 by Human Organoids JO: Phenomics http://www.kidney.de/pget.php?&tw=1&pmid=35233559 #FOAvip Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has created an immense menace to public health worldwide, exerting huge effects on global economic and political conditions. Understanding the biology and pathogenesis mechanisms of this novel virus, in large parts, relies on optimal physiological models that allow replication and propagation of SARS-CoV-2. Human organoids, derived from stem cells, are three-dimensional cell cultures that recapitulate the cellular organization, transcriptional and epigenetic signatures of their counterpart organs. Recent studies have indicated their great values as experimental virology platforms, making human organoid an ideal tool for investigating host-pathogen interactions. Here, we summarize research developments for SARS-CoV-2 infection of various human organoids involved in multiple systems, including lung, liver, brain, intestine, kidney and blood vessel organoids. These studies help us reveal the pathogenesis mechanism of COVID-19, and facilitate the development of effective vaccines and drugs as well as other therapeutic regimes. Twit Text FOAVip Defense of COVID-19 by Human Organoids ????Phenomics http://www.kidney.de/pget.php?&tw=1&pmid=35233559 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35233559 #FOAvip English Wikipedia <ref>{{Cite pmid|35233559}}</ref> Defense of COVID-19 by Human Organoids #MMPMID35233559 Lv T; Meng F; Yu M; Huang H; Lin X; Zhao B Phenomics 2021[]; 1 (3): 113-128 PMID35233559show ga Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has created an immense menace to public health worldwide, exerting huge effects on global economic and political conditions. Understanding the biology and pathogenesis mechanisms of this novel virus, in large parts, relies on optimal physiological models that allow replication and propagation of SARS-CoV-2. Human organoids, derived from stem cells, are three-dimensional cell cultures that recapitulate the cellular organization, transcriptional and epigenetic signatures of their counterpart organs. Recent studies have indicated their great values as experimental virology platforms, making human organoid an ideal tool for investigating host-pathogen interactions. Here, we summarize research developments for SARS-CoV-2 infection of various human organoids involved in multiple systems, including lung, liver, brain, intestine, kidney and blood vessel organoids. These studies help us reveal the pathogenesis mechanism of COVID-19, and facilitate the development of effective vaccines and drugs as well as other therapeutic regimes. äDefense of COVID-19 by Human Organoids (epmc).pdf DeepDyve Pubget Overpricing