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10.1093/bib/bbac045 http://scihub22266oqcxt.onion/10.1093/bib/bbac045 35229157!9116216!35229157     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Brief+Bioinform 2022 ; 23 (3): ä Nephropedia Template TP {{tp|p=35229157|t=2022. Unheeded SARS-CoV-2 proteins? A deep look into negative-sense RNA |pdf=|usr=}}{{35229157}} gab.com Text Unheeded SARS-CoV-2 proteins A deep look into negative-sense RNA JO: Brief Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=35229157 #FOAvip SARS-CoV-2 is a novel positive-sense single-stranded RNA virus from the Coronaviridae family (genus Betacoronavirus), which has been established as causing the COVID-19 pandemic. The genome of SARS-CoV-2 is one of the largest among known RNA viruses, comprising of at least 26 known protein-coding loci. Studies thus far have outlined the coding capacity of the positive-sense strand of the SARS-CoV-2 genome, which can be used directly for protein translation. However, it has been recently shown that transcribed negative-sense viral RNA intermediates that arise during viral genome replication from positive-sense viruses can also code for proteins. No studies have yet explored the potential for negative-sense SARS-CoV-2 RNA intermediates to contain protein-coding loci. Thus, using sequence and structure-based bioinformatics methodologies, we have investigated the presence and validity of putative negative-sense ORFs (nsORFs) in the SARS-CoV-2 genome. Nine nsORFs were discovered to contain strong eukaryotic translation initiation signals and high codon adaptability scores, and several of the nsORFs were predicted to interact with RNA-binding proteins. Evolutionary conservation analyses indicated that some of the nsORFs are deeply conserved among related coronaviruses. Three-dimensional protein modeling revealed the presence of higher order folding among all putative SARS-CoV-2 nsORFs, and subsequent structural mimicry analyses suggest similarity of the nsORFs to DNA/RNA-binding proteins and proteins involved in immune signaling pathways. Altogether, these results suggest the potential existence of still undescribed SARS-CoV-2 proteins, which may play an important role in the viral lifecycle and COVID-19 pathogenesis. Twit Text FOAVip Unheeded SARS-CoV-2 proteins A deep look into negative-sense RNA ????Brief Bioinform http://www.kidney.de/pget.php?&tw=1&pmid=35229157 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35229157 #FOAvip English Wikipedia <ref>{{Cite pmid|35229157}}</ref> Unheeded SARS-CoV-2 proteins? A deep look into negative-sense RNA #MMPMID35229157 Bartas M; Volna A; Beaudoin CA; Poulsen ET; Cerven J; Brazda V; Spunda V; Blundell TL; Pecinka P Brief Bioinform 2022[May]; 23 (3): ä PMID35229157show ga SARS-CoV-2 is a novel positive-sense single-stranded RNA virus from the Coronaviridae family (genus Betacoronavirus), which has been established as causing the COVID-19 pandemic. The genome of SARS-CoV-2 is one of the largest among known RNA viruses, comprising of at least 26 known protein-coding loci. Studies thus far have outlined the coding capacity of the positive-sense strand of the SARS-CoV-2 genome, which can be used directly for protein translation. However, it has been recently shown that transcribed negative-sense viral RNA intermediates that arise during viral genome replication from positive-sense viruses can also code for proteins. No studies have yet explored the potential for negative-sense SARS-CoV-2 RNA intermediates to contain protein-coding loci. Thus, using sequence and structure-based bioinformatics methodologies, we have investigated the presence and validity of putative negative-sense ORFs (nsORFs) in the SARS-CoV-2 genome. Nine nsORFs were discovered to contain strong eukaryotic translation initiation signals and high codon adaptability scores, and several of the nsORFs were predicted to interact with RNA-binding proteins. Evolutionary conservation analyses indicated that some of the nsORFs are deeply conserved among related coronaviruses. Three-dimensional protein modeling revealed the presence of higher order folding among all putative SARS-CoV-2 nsORFs, and subsequent structural mimicry analyses suggest similarity of the nsORFs to DNA/RNA-binding proteins and proteins involved in immune signaling pathways. Altogether, these results suggest the potential existence of still undescribed SARS-CoV-2 proteins, which may play an important role in the viral lifecycle and COVID-19 pathogenesis. |*COVID-19/genetics[MESH] |*SARS-CoV-2/genetics[MESH] |Genome, Viral[MESH] |Humans[MESH] |Pandemics[MESH] |RNA, Viral/chemistry/genetics[MESH]Unheeded SARS-CoV-2 proteins? A deep look into negative-sense RNA (epmc).pdf DeepDyve Pubget Overpricing