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10.1016/j.isci.2022.103971 http://scihub22266oqcxt.onion/10.1016/j.isci.2022.103971 35224470!8863325!35224470     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       iScience 2022 ; 25 (3): 103971 Nephropedia Template TP {{tp|p=35224470|t=2022. Coagulation factor V is a T-cell inhibitor expressed by leukocytes in COVID-19 |pdf=|usr=}}{{35224470}} gab.com Text Coagulation factor V is a T-cell inhibitor expressed by leukocytes in COVID-19 JO: iScience http://www.kidney.de/pget.php?&tw=1&pmid=35224470 #FOAvip Clotting Factor V (FV) is primarily synthesized in the liver and when cleaved by thrombin forms pro-coagulant Factor Va (FVa). Using whole blood RNAseq and scRNAseq of peripheral blood mononuclear cells, we find that FV mRNA is expressed in leukocytes, and identify neutrophils, monocytes, and T regulatory cells as sources of increased FV in hospitalized patients with COVID-19. Proteomic analysis confirms increased FV in circulating neutrophils in severe COVID-19, and immunofluorescence microscopy identifies FV in lung-infiltrating leukocytes in COVID-19 lung disease. Increased leukocyte FV expression in severe disease correlates with T-cell lymphopenia. Both plasma-derived and a cleavage resistant recombinant FV, but not thrombin cleaved FVa, suppress T-cell proliferation in vitro. Anticoagulants that reduce FV conversion to FVa, including heparin, may have the unintended consequence of suppressing the adaptive immune system. Twit Text FOAVip Coagulation factor V is a T-cell inhibitor expressed by leukocytes in COVID-19 ????iScience http://www.kidney.de/pget.php?&tw=1&pmid=35224470 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=35224470 #FOAvip English Wikipedia <ref>{{Cite pmid|35224470}}</ref> Coagulation factor V is a T-cell inhibitor expressed by leukocytes in COVID-19 #MMPMID35224470 Wang J; Kotagiri P; Lyons PA; Al-Lamki RS; Mescia F; Bergamaschi L; Turner L; Morgan MD; Calero-Nieto FJ; Bach K; Mende N; Wilson NK; Watts ER; Maxwell PH; Chinnery PF; Kingston N; Papadia S; Stirrups KE; Walker N; Gupta RK; Menon DK; Allinson K; Aitken SJ; Toshner M; Weekes MP; Nathan JA; Walmsley SR; Ouwehand WH; Kasanicki M; Gottgens B; Marioni JC; Smith KGC; Pober JS; Bradley JR iScience 2022[Mar]; 25 (3): 103971 PMID35224470show ga Clotting Factor V (FV) is primarily synthesized in the liver and when cleaved by thrombin forms pro-coagulant Factor Va (FVa). Using whole blood RNAseq and scRNAseq of peripheral blood mononuclear cells, we find that FV mRNA is expressed in leukocytes, and identify neutrophils, monocytes, and T regulatory cells as sources of increased FV in hospitalized patients with COVID-19. Proteomic analysis confirms increased FV in circulating neutrophils in severe COVID-19, and immunofluorescence microscopy identifies FV in lung-infiltrating leukocytes in COVID-19 lung disease. Increased leukocyte FV expression in severe disease correlates with T-cell lymphopenia. Both plasma-derived and a cleavage resistant recombinant FV, but not thrombin cleaved FVa, suppress T-cell proliferation in vitro. Anticoagulants that reduce FV conversion to FVa, including heparin, may have the unintended consequence of suppressing the adaptive immune system. äCoagulation factor V is a T-cell inhibitor expressed by leukocytes in (epmc).pdf DeepDyve Pubget Overpricing